dorsal/arxiv
View SchemaA Physical Model for the Condensation and Decondensation of Eukaryotic Chromosomes
| Authors | Julien Mozziconacci, Christophe Lavelle, Maria Barbi, Annick Lesne, Jean-Marc Victor |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0512027 |
| URL | https://arxiv.org/abs/q-bio/0512027 |
| DOI | 10.1016/j.febslet.2005.12.053 |
| Journal | FEBS Letters 580 (2006) 368-372 |
Abstract
During the eukaryotic cell cycle, chromatin undergoes several conformational changes, which are believed to play key roles in gene expression regulation during interphase, and in genome replication and division during mitosis. In this paper, we propose a scenario for chromatin structural reorganization during mitosis, which bridges all the different scales involved in chromatin architecture, from nucleosomes to chromatin loops. We build a model for chromatin, based on available data, taking into account both physical and topological constraints DNA has to deal with. Our results suggest that the mitotic chromosome condensation/decondensation process is induced by a structural change at the level of the nucleosome itself.
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"abstract": "During the eukaryotic cell cycle, chromatin undergoes several conformational\nchanges, which are believed to play key roles in gene expression regulation\nduring interphase, and in genome replication and division during mitosis. In\nthis paper, we propose a scenario for chromatin structural reorganization\nduring mitosis, which bridges all the different scales involved in chromatin\narchitecture, from nucleosomes to chromatin loops. We build a model for\nchromatin, based on available data, taking into account both physical and\ntopological constraints DNA has to deal with. Our results suggest that the\nmitotic chromosome condensation/decondensation process is induced by a\nstructural change at the level of the nucleosome itself.",
"arxiv_id": "q-bio/0512027",
"authors": [
"Julien Mozziconacci",
"Christophe Lavelle",
"Maria Barbi",
"Annick Lesne",
"Jean-Marc Victor"
],
"categories": [
"q-bio.SC"
],
"doi": "10.1016/j.febslet.2005.12.053",
"journal_ref": "FEBS Letters 580 (2006) 368-372",
"title": "A Physical Model for the Condensation and Decondensation of Eukaryotic Chromosomes",
"url": "https://arxiv.org/abs/q-bio/0512027"
},
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