dorsal/arxiv
View SchemaFacilitated diffusion of DNA-binding proteins
| Authors | Konstantin V. Klenin, Holger Merlitz, Joerg Langowski, Chen-Xu Wu |
|---|---|
| Categories | |
| ArXiv ID | physics/0507056 |
| URL | https://arxiv.org/abs/physics/0507056 |
| DOI | 10.1103/PhysRevLett.96.018104 |
| Journal | Phys. Rev. Lett. 96(1) (2006) 18104 |
Abstract
The diffusion-controlled limit of reaction times for site-specific DNA-binding proteins is derived from first principles. We follow the generally accepted concept that a protein propagates via two competitive modes, a three-dimensional diffusion in space and a one-dimensional sliding along the DNA. However, our theoretical treatment of the problem is new. The accuracy of our analytical model is verified by numerical simulations. The results confirm that the unspecific binding of protein to DNA, combined with sliding, is capable to reduce the reaction times significantly.
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"abstract": "The diffusion-controlled limit of reaction times for site-specific\nDNA-binding proteins is derived from first principles. We follow the generally\naccepted concept that a protein propagates via two competitive modes, a\nthree-dimensional diffusion in space and a one-dimensional sliding along the\nDNA. However, our theoretical treatment of the problem is new. The accuracy of\nour analytical model is verified by numerical simulations. The results confirm\nthat the unspecific binding of protein to DNA, combined with sliding, is\ncapable to reduce the reaction times significantly.",
"arxiv_id": "physics/0507056",
"authors": [
"Konstantin V. Klenin",
"Holger Merlitz",
"Joerg Langowski",
"Chen-Xu Wu"
],
"categories": [
"physics.bio-ph",
"physics.comp-ph"
],
"doi": "10.1103/PhysRevLett.96.018104",
"journal_ref": "Phys. Rev. Lett. 96(1) (2006) 18104",
"title": "Facilitated diffusion of DNA-binding proteins",
"url": "https://arxiv.org/abs/physics/0507056"
},
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