{
  "annotation_id": "62f8cb4d-018f-49a4-aa3f-a4b273f63949",
  "date_created": "2026-03-02T18:01:31.681000Z",
  "date_modified": "2026-03-02T18:01:31.681000Z",
  "file_hash": "a09fe8577f48a0f77a8f6e13f0bb49fda396a781cfdcdc5fb8d97cfc7618e323",
  "private": false,
  "record": {
    "abstract": "We study the joint effect of thermal bath fluctuations and an external noise\ntuning activity of cytotoxic cells on the triggered immune response in a\ngrowing cancerous tissue. The immune response is assumed to be primarily\nmediated by effector cells that develop a cytotoxic activity against the\nabnormal tissue. The kinetics of such a reaction is represented by an\nenzymatic-like Michaelis-Menten two step process. Effective free-energy surface\nfor the process is further parametrized by the fluctuating energy barrier\nbetween the states of high and low concentration of cancerous cells. By\nanalyzing the far from equilibrium escape problem across the fluctuating\npotential barrier, we determine condtions of the most efficient decay kinetics\nof the cancer cell-population in the presence of dichotomously fluctuating\nconcentration of cytotoxic cells.",
    "arxiv_id": "q-bio/0403041",
    "authors": [
      "Anna Ochab-Marcinek",
      "Ewa Gudowska-Nowak"
    ],
    "categories": [
      "q-bio.PE",
      "cond-mat.stat-mech"
    ],
    "doi": "10.1016/j.physa.2004.06.071",
    "journal_ref": "Physica A 343 (2004) 557-572",
    "title": "Population growth and control in stochastic models of cancer development",
    "url": "https://arxiv.org/abs/q-bio/0403041"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "07cc174b-3a91-4769-b29b-019de0996e45",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}