{
  "annotation_id": "62edb469-ed70-4448-9d52-b14046e7caab",
  "date_created": "2026-03-02T18:01:30.962000Z",
  "date_modified": "2026-03-02T18:01:30.962000Z",
  "file_hash": "b5c6b98d6f0482a87cc8bbcdbdfef1a1c7d613238f4f761ee3811bc96d6c2eda",
  "private": false,
  "record": {
    "abstract": "Molecular combing is a powerful and simple method for aligning DNA molecules\nonto a surface. Using this technique combined with fluorescence microscopy, we\nobserved that the length of lambda-DNA molecules was extended to about 1.6\ntimes their contour length (unextended length, 16.2 micrometers) by the combing\nmethod on hydrophobic polymethylmetacrylate (PMMA) coated surfaces. The effects\nof sodium and magnesium ions and pH of the DNA solution were investigated.\nInterestingly, we observed force-induced melting of single DNA molecules.",
    "arxiv_id": "q-bio/0312035",
    "authors": [
      "Yu-Ying Liu",
      "Peng-Ye Wang",
      "Shuo-Xing Dou",
      "Wei-Chi Wang",
      "Ping Xie",
      "Hua-Wei Yin",
      "Xing-Dong Zhang"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "doi": "10.1063/1.1777220",
    "journal_ref": "JOURNAL OF CHEMICAL PHYSICS, 121, 4302 (2004)",
    "title": "Ionic effect on combing of single DNA molecules and observation of their   force-induced melting by fluorescence microscopy",
    "url": "https://arxiv.org/abs/q-bio/0312035"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "e5e0071c-0c6a-49af-9fe3-ba4e1f40675b",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}