dorsal/arxiv
View SchemaAnalytical study of the effect of recombination on evolution via DNA shuffling
| Authors | Weiqun Peng, Herbert Levine, Terence Hwa, David A. Kessler |
|---|---|
| Categories | |
| ArXiv ID | physics/0303120 |
| URL | https://arxiv.org/abs/physics/0303120 |
| DOI | 10.1103/PhysRevE.69.051911 |
Abstract
We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. This model incorporates selection, recombination and point mutations. The simplicity of the model allows us to obtain a full analytical treatment of both its dynamical and equilibrium properties, for the case of an infinite population. We also briefly discuss finite population size corrections.
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"abstract": "We investigate a multi-locus evolutionary model which is based on the DNA\nshuffling protocol widely applied in \\textit{in vitro} directed evolution. This\nmodel incorporates selection, recombination and point mutations. The simplicity\nof the model allows us to obtain a full analytical treatment of both its\ndynamical and equilibrium properties, for the case of an infinite population.\nWe also briefly discuss finite population size corrections.",
"arxiv_id": "physics/0303120",
"authors": [
"Weiqun Peng",
"Herbert Levine",
"Terence Hwa",
"David A. Kessler"
],
"categories": [
"physics.bio-ph",
"cond-mat.stat-mech",
"q-bio.PE"
],
"doi": "10.1103/PhysRevE.69.051911",
"title": "Analytical study of the effect of recombination on evolution via DNA shuffling",
"url": "https://arxiv.org/abs/physics/0303120"
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