{
  "annotation_id": "61548e3e-f2ed-47aa-9b85-45345da8f9fe",
  "date_created": "2026-03-02T18:01:31.019000Z",
  "date_modified": "2026-03-02T18:01:31.019000Z",
  "file_hash": "cd97798d1f69cb3148d0185254b3beb71b8258d4ad00127f7e87324854f3887e",
  "private": false,
  "record": {
    "abstract": "The vertebrate immune system is a wonder of modern evolution. Occasionally,\nhowever, correlations within the immune system lead to inappropriate\nrecruitment of preexisting T cells against novel viral diseases. We present a\nrandom energy theory for the correlations in the naive and memory T cell immune\nresponses. The non-linear susceptibility of the random energy model to\nstructural changes captures the correlations in the immune response to mutated\nantigens. We show how the sequence-level diversity of the T cell repertoire\ndrives the dynamics of the immune response against mutated viral antigens.",
    "arxiv_id": "q-bio/0404023",
    "authors": [
      "Jeong-Man Park",
      "Michael W. Deem"
    ],
    "categories": [
      "q-bio.BM",
      "q-bio.QM"
    ],
    "doi": "10.1016/j.physa.2004.04.127",
    "title": "Correlations in the T Cell Response to Altered Peptide Ligands",
    "url": "https://arxiv.org/abs/q-bio/0404023"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "351435c8-801b-4ecc-93de-a22edf3090e8",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}