dorsal/arxiv
View SchemaMagnetophoretic separation of blood cells at the microscale
| Authors | E. P. Furlani |
|---|---|
| Categories | |
| ArXiv ID | physics/0612005 |
| URL | https://arxiv.org/abs/physics/0612005 |
Abstract
We present a method and model for the direct and continuous separation of red and white blood cells in plasma. The method is implemented at the microscale using a microfluidic system that consists of an array of integrated soft-magnetic elements embedded beneath a microfluidic channel. The microsystem is passive, and is activated via application of a bias field that magnetizes the elements. Once magnetized, the elements produce a nonuniform magnetic field distribution in the microchannel, which gives rise to a force on blood cells as they pass through the microsystem. In whole blood, white blood cells behave as diamagnetic microparticles while red blood cells exhibit diamagnetic or paramagnetic behavior depending on the oxygenation of their hemoglobin. We develop a mathematical model for predicting the motion of blood cells in the microsystem that takes into account the dominant magnetic, fluidic and buoyant forces on the cells. We use the model to study red/white blood cell transport, and our analysis indicates that the microsystem is capable of rapid and efficient red/white blood cell separation.
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"abstract": "We present a method and model for the direct and continuous separation of red\nand white blood cells in plasma. The method is implemented at the microscale\nusing a microfluidic system that consists of an array of integrated\nsoft-magnetic elements embedded beneath a microfluidic channel. The microsystem\nis passive, and is activated via application of a bias field that magnetizes\nthe elements. Once magnetized, the elements produce a nonuniform magnetic field\ndistribution in the microchannel, which gives rise to a force on blood cells as\nthey pass through the microsystem. In whole blood, white blood cells behave as\ndiamagnetic microparticles while red blood cells exhibit diamagnetic or\nparamagnetic behavior depending on the oxygenation of their hemoglobin. We\ndevelop a mathematical model for predicting the motion of blood cells in the\nmicrosystem that takes into account the dominant magnetic, fluidic and buoyant\nforces on the cells. We use the model to study red/white blood cell transport,\nand our analysis indicates that the microsystem is capable of rapid and\nefficient red/white blood cell separation.",
"arxiv_id": "physics/0612005",
"authors": [
"E. P. Furlani"
],
"categories": [
"physics.bio-ph",
"physics.med-ph"
],
"title": "Magnetophoretic separation of blood cells at the microscale",
"url": "https://arxiv.org/abs/physics/0612005"
},
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