{
  "annotation_id": "5e008909-0602-4440-86ab-d9829a8baf79",
  "date_created": "2026-03-02T18:00:43.479000Z",
  "date_modified": "2026-03-02T18:00:43.479000Z",
  "file_hash": "ef5668ae03d4a48bd19caffceb99d02703647d612fe084a8f0b8521eb6c441ae",
  "private": false,
  "record": {
    "abstract": "The influx of calcium ions into the dendritic spines through the\nN-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for\nvarious forms of synaptic plasticity. In this paper, the authors calculate\nanalytically the mean values of the calcium transients elicited by a spiking\nneuron undergoing a simple model of ionic currents and back-propagating action\npotentials. The relative variability of these transients, due to the stochastic\nnature of synaptic transmission, is further considered using a simple Markov\nmodel of NMDA receptos. One finds that both the mean value and the variability\ndepend on the timing between pre- and postsynaptic action-potentials. These\nresults could have implications on the expected form of synaptic-plasticity\ncurve and can form a basis for a unified theory of spike time-dependent, and\nrate based plasticity.",
    "arxiv_id": "physics/0304075",
    "authors": [
      "Luk C. Yeung",
      "Gastone C. Castellani",
      "Harel Z. Shouval"
    ],
    "categories": [
      "physics.bio-ph",
      "q-bio"
    ],
    "doi": "10.1103/PhysRevE.69.011907",
    "title": "Analysis of the intraspinal calcium dynamics and its implications on the   plasticity of spiking neurons",
    "url": "https://arxiv.org/abs/physics/0304075"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "b57ae6e9-f38e-43b2-a19e-9e47a60ead22",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}