dorsal/arxiv
View SchemaAnalysis of the intraspinal calcium dynamics and its implications on the plasticity of spiking neurons
| Authors | Luk C. Yeung, Gastone C. Castellani, Harel Z. Shouval |
|---|---|
| Categories | |
| ArXiv ID | physics/0304075 |
| URL | https://arxiv.org/abs/physics/0304075 |
| DOI | 10.1103/PhysRevE.69.011907 |
Abstract
The influx of calcium ions into the dendritic spines through the N-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for various forms of synaptic plasticity. In this paper, the authors calculate analytically the mean values of the calcium transients elicited by a spiking neuron undergoing a simple model of ionic currents and back-propagating action potentials. The relative variability of these transients, due to the stochastic nature of synaptic transmission, is further considered using a simple Markov model of NMDA receptos. One finds that both the mean value and the variability depend on the timing between pre- and postsynaptic action-potentials. These results could have implications on the expected form of synaptic-plasticity curve and can form a basis for a unified theory of spike time-dependent, and rate based plasticity.
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"abstract": "The influx of calcium ions into the dendritic spines through the\nN-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for\nvarious forms of synaptic plasticity. In this paper, the authors calculate\nanalytically the mean values of the calcium transients elicited by a spiking\nneuron undergoing a simple model of ionic currents and back-propagating action\npotentials. The relative variability of these transients, due to the stochastic\nnature of synaptic transmission, is further considered using a simple Markov\nmodel of NMDA receptos. One finds that both the mean value and the variability\ndepend on the timing between pre- and postsynaptic action-potentials. These\nresults could have implications on the expected form of synaptic-plasticity\ncurve and can form a basis for a unified theory of spike time-dependent, and\nrate based plasticity.",
"arxiv_id": "physics/0304075",
"authors": [
"Luk C. Yeung",
"Gastone C. Castellani",
"Harel Z. Shouval"
],
"categories": [
"physics.bio-ph",
"q-bio"
],
"doi": "10.1103/PhysRevE.69.011907",
"title": "Analysis of the intraspinal calcium dynamics and its implications on the plasticity of spiking neurons",
"url": "https://arxiv.org/abs/physics/0304075"
},
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