dorsal/arxiv
View SchemaDetection of confinement and jumps in single molecule membrane trajectories
| Authors | N. Meilhac, L. Le Guyader, L. Salome, N. Destainville |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0507031 |
| URL | https://arxiv.org/abs/q-bio/0507031 |
| DOI | 10.1103/PhysRevE.73.011915 |
| Journal | Phys. Rev. E 73, 011915 (2006) |
Abstract
We propose a novel variant of the algorithm by Simson et al. [R. Simson, E.D. Sheets, K. Jacobson, Biophys. J. 69, 989 (1995)]. Their algorithm was developed to detect transient confinement zones in experimental single particle tracking trajectories of diffusing membrane proteins or lipids. We show that our algorithm is able to detect confinement in a wider class of confining potential shapes than Simson et al.'s one. Furthermore it enables to detect not only temporary confinement but also jumps between confinement zones. Jumps are predicted by membrane skeleton fence and picket models. In the case of experimental trajectories of $\mu$-opioid receptors, which belong to the family of G-protein-coupled receptors involved in a signal transduction pathway, this algorithm confirms that confinement cannot be explained solely by rigid fences.
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"abstract": "We propose a novel variant of the algorithm by Simson et al. [R. Simson, E.D.\nSheets, K. Jacobson, Biophys. J. 69, 989 (1995)]. Their algorithm was developed\nto detect transient confinement zones in experimental single particle tracking\ntrajectories of diffusing membrane proteins or lipids. We show that our\nalgorithm is able to detect confinement in a wider class of confining potential\nshapes than Simson et al.\u0027s one. Furthermore it enables to detect not only\ntemporary confinement but also jumps between confinement zones. Jumps are\npredicted by membrane skeleton fence and picket models. In the case of\nexperimental trajectories of $\\mu$-opioid receptors, which belong to the family\nof G-protein-coupled receptors involved in a signal transduction pathway, this\nalgorithm confirms that confinement cannot be explained solely by rigid fences.",
"arxiv_id": "q-bio/0507031",
"authors": [
"N. Meilhac",
"L. Le Guyader",
"L. Salome",
"N. Destainville"
],
"categories": [
"q-bio.QM",
"cond-mat.stat-mech",
"q-bio.SC"
],
"doi": "10.1103/PhysRevE.73.011915",
"journal_ref": "Phys. Rev. E 73, 011915 (2006)",
"title": "Detection of confinement and jumps in single molecule membrane trajectories",
"url": "https://arxiv.org/abs/q-bio/0507031"
},
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