dorsal/arxiv
View SchemaCapacitance fluctuations causing channel noise reduction in stochastic Hodgkin-Huxley systems
| Authors | G. Schmid, I. Goychuk, P. Hanggi |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0611040 |
| URL | https://arxiv.org/abs/q-bio/0611040 |
| DOI | 10.1088/1478-3975/3/4/002 |
| Journal | Physical Biology 3, 248254 (2006) |
Abstract
Voltage-dependent ion channels determine the electric properties of axonal cell membranes. They not only allow the passage of ions through the cell membrane but also contribute to an additional charging of the cell membrane resulting in the so-called capacitance loading. The switching of the channel gates between an open and a closed configuration is intrinsically related to the movement of gating charge within the cell membrane. At the beginning of an action potential the transient gating current is opposite to the direction of the current of sodium ions through the membrane. Therefore, the excitability is expected to become reduced due to the influence of a gating current. Our stochastic Hodgkin-Huxley like modeling takes into account both the channel noise -- i.e. the fluctuations of the number of open ion channels -- and the capacitance fluctuations that result from the dynamics of the gating charge. We investigate the spiking dynamics of membrane patches of variable size and analyze the statistics of the spontaneous spiking. As a main result, we find that the gating currents yield a drastic reduction of the spontaneous spiking rate for sufficiently large ion channel clusters. Consequently, this demonstrates a prominent mechanism for channel noise reduction.
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"abstract": "Voltage-dependent ion channels determine the electric properties of axonal\ncell membranes. They not only allow the passage of ions through the cell\nmembrane but also contribute to an additional charging of the cell membrane\nresulting in the so-called capacitance loading. The switching of the channel\ngates between an open and a closed configuration is intrinsically related to\nthe movement of gating charge within the cell membrane. At the beginning of an\naction potential the transient gating current is opposite to the direction of\nthe current of sodium ions through the membrane. Therefore, the excitability is\nexpected to become reduced due to the influence of a gating current. Our\nstochastic Hodgkin-Huxley like modeling takes into account both the channel\nnoise -- i.e. the fluctuations of the number of open ion channels -- and the\ncapacitance fluctuations that result from the dynamics of the gating charge. We\ninvestigate the spiking dynamics of membrane patches of variable size and\nanalyze the statistics of the spontaneous spiking. As a main result, we find\nthat the gating currents yield a drastic reduction of the spontaneous spiking\nrate for sufficiently large ion channel clusters. Consequently, this\ndemonstrates a prominent mechanism for channel noise reduction.",
"arxiv_id": "q-bio/0611040",
"authors": [
"G. Schmid",
"I. Goychuk",
"P. Hanggi"
],
"categories": [
"q-bio.NC",
"q-bio.SC"
],
"doi": "10.1088/1478-3975/3/4/002",
"journal_ref": "Physical Biology 3, 248254 (2006)",
"title": "Capacitance fluctuations causing channel noise reduction in stochastic Hodgkin-Huxley systems",
"url": "https://arxiv.org/abs/q-bio/0611040"
},
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