dorsal/arxiv
View SchemaStretching of proteins in a force-clamp
| Authors | Piotr Szymczak, Marek Cieplak |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0512004 |
| URL | https://arxiv.org/abs/q-bio/0512004 |
Abstract
Mechanically induced protein unfolding in the force-clamp apparatus is shown, in a coarse-grained model of ubiquitin, to have lognormal statistics above a treshold force and exponential below it. Correspondingly, the mean unfolding time is slowly varying and exponentially decreases as a function of the force. The time dependencies of the end-to-end distances are also distinct. The time sequence of unfolding events weakly depends on force and much of it resembles that for stretching at constant speed. A more complicated time dependence arises for integrin.
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"abstract": "Mechanically induced protein unfolding in the force-clamp apparatus is shown,\nin a coarse-grained model of ubiquitin, to have lognormal statistics above a\ntreshold force and exponential below it. Correspondingly, the mean unfolding\ntime is slowly varying and exponentially decreases as a function of the force.\nThe time dependencies of the end-to-end distances are also distinct. The time\nsequence of unfolding events weakly depends on force and much of it resembles\nthat for stretching at constant speed. A more complicated time dependence\narises for integrin.",
"arxiv_id": "q-bio/0512004",
"authors": [
"Piotr Szymczak",
"Marek Cieplak"
],
"categories": [
"q-bio.BM",
"cond-mat.soft"
],
"title": "Stretching of proteins in a force-clamp",
"url": "https://arxiv.org/abs/q-bio/0512004"
},
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