dorsal/arxiv
View SchemaUbiquity of Log-normal Distributions in Intra-cellular Reaction Dynamic
| Authors | Chikara Furusawa, Takao Suzuki, Akiko Kashiwagi, Tetsuya Yomo, Kunihiko Kaneko |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0503040 |
| URL | https://arxiv.org/abs/q-bio/0503040 |
| Journal | BIOPHYSICS, 1 (2005) pp. 25 |
Abstract
The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. First, the chemical abundances measured over many cells are found to obey a log-normal distribution and second, the relationship between the average and standard deviation of the abundances is found to be linear. The ubiquity of the laws is explored both theoretically and experimentally. First by means of a model with a catalytic reaction network, the laws are shown to appear near the critical state with efficient self-reproduction. Second by measuring distributions of fluorescent proteins in bacteria cells the ubiquity of log-normal distribution of protein abundances is confirmed. Relevance of these findings to cellular function and biological plasticity is briefly discussed.
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"abstract": "The discovery of two fundamental laws concerning cellular dynamics with\nrecursive growth is reported. First, the chemical abundances measured over many\ncells are found to obey a log-normal distribution and second, the relationship\nbetween the average and standard deviation of the abundances is found to be\nlinear. The ubiquity of the laws is explored both theoretically and\nexperimentally. First by means of a model with a catalytic reaction network,\nthe laws are shown to appear near the critical state with efficient\nself-reproduction. Second by measuring distributions of fluorescent proteins in\nbacteria cells the ubiquity of log-normal distribution of protein abundances is\nconfirmed. Relevance of these findings to cellular function and biological\nplasticity is briefly discussed.",
"arxiv_id": "q-bio/0503040",
"authors": [
"Chikara Furusawa",
"Takao Suzuki",
"Akiko Kashiwagi",
"Tetsuya Yomo",
"Kunihiko Kaneko"
],
"categories": [
"q-bio.MN"
],
"journal_ref": "BIOPHYSICS, 1 (2005) pp. 25",
"title": "Ubiquity of Log-normal Distributions in Intra-cellular Reaction Dynamic",
"url": "https://arxiv.org/abs/q-bio/0503040"
},
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