dorsal/arxiv
View SchemaMechanisms of noise-resistance in genetic oscillators
| Authors | Jose M. G. Vilar, Hao Yuan Kueh, Naama Barkai, Stanislas Leibler |
|---|---|
| Categories | |
| ArXiv ID | physics/0208044 |
| URL | https://arxiv.org/abs/physics/0208044 |
| DOI | 10.1073/pnas.092133899 |
| Journal | Proc. Natl. Acad. Sci. USA 99, 5988-5992 (2002) |
Abstract
A wide range of organisms use circadian clocks to keep internal sense of daily time and regulate their behavior accordingly. Most of these clocks use intracellular genetic networks based on positive and negative regulatory elements. The integration of these "circuits" at the cellular level imposes strong constraints on their functioning and design. Here we study a recently proposed model [N. Barkai and S. Leibler, Nature, 403:267--268, 2000] that incorporates just the essential elements found experimentally. We show that this type of oscillator is driven mainly by two elements: the concentration of a repressor protein and the dynamics of an activator protein forming an inactive complex with the repressor. Thus the clock does not need to rely on mRNA dynamics to oscillate, which makes it especially resistant to fluctuations. Oscillations can be present even when the time average of the number of mRNA molecules goes below one. Under some conditions, this oscillator is not only resistant to but paradoxically also enhanced by the intrinsic biochemical noise.
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"abstract": "A wide range of organisms use circadian clocks to keep internal sense of\ndaily time and regulate their behavior accordingly. Most of these clocks use\nintracellular genetic networks based on positive and negative regulatory\nelements. The integration of these \"circuits\" at the cellular level imposes\nstrong constraints on their functioning and design. Here we study a recently\nproposed model [N. Barkai and S. Leibler, Nature, 403:267--268, 2000] that\nincorporates just the essential elements found experimentally. We show that\nthis type of oscillator is driven mainly by two elements: the concentration of\na repressor protein and the dynamics of an activator protein forming an\ninactive complex with the repressor. Thus the clock does not need to rely on\nmRNA dynamics to oscillate, which makes it especially resistant to\nfluctuations. Oscillations can be present even when the time average of the\nnumber of mRNA molecules goes below one. Under some conditions, this oscillator\nis not only resistant to but paradoxically also enhanced by the intrinsic\nbiochemical noise.",
"arxiv_id": "physics/0208044",
"authors": [
"Jose M. G. Vilar",
"Hao Yuan Kueh",
"Naama Barkai",
"Stanislas Leibler"
],
"categories": [
"physics.bio-ph",
"cond-mat",
"q-bio.MN"
],
"doi": "10.1073/pnas.092133899",
"journal_ref": "Proc. Natl. Acad. Sci. USA 99, 5988-5992 (2002)",
"title": "Mechanisms of noise-resistance in genetic oscillators",
"url": "https://arxiv.org/abs/physics/0208044"
},
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