dorsal/arxiv
View SchemaEffect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model
| Authors | Gerhard Schmid, Igor Goychuk, Peter Hanggi |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0601013 |
| URL | https://arxiv.org/abs/q-bio/0601013 |
| DOI | 10.1088/1478-3967/1/2/002 |
| Journal | PHYSICAL BIOLOGY 1, pp. 61-66 (2004) |
Abstract
The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model. Internal noise stemming from the stochastic dynamics of individual ion channels is known to affect the collective properties of the whole ion channel cluster. For example, there exists an optimal size of the membrane patch for which the internal noise alone causes a regular spontaneous generation of action potentials. In addition to varying the size of ion channel clusters, living organisms may adapt the densities of ion channels in order to optimally regulate the spontaneous spiking activity. The influence of channel block on the excitability of a membrane patch of certain size is twofold: First, a variation of ion channel densities primarily yields a change of the conductance level. Second, a down-regulation of working ion channels always increases the channel noise. While the former effect dominates in the case of sodium channel block resulting in a reduced spiking activity, the latter enhances the generation of spontaneous action potentials in the case of a tailored potassium channel blocking. Moreover, by blocking some portion of either potassium or sodium ion channels, it is possible to either increase or to decrease the regularity of the spike train.
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"abstract": "The influence of intrinsic channel noise on the spontaneous spiking activity\nof poisoned excitable membrane patches is studied by use of a stochastic\ngeneralization of the Hodgkin-Huxley model. Internal noise stemming from the\nstochastic dynamics of individual ion channels is known to affect the\ncollective properties of the whole ion channel cluster. For example, there\nexists an optimal size of the membrane patch for which the internal noise alone\ncauses a regular spontaneous generation of action potentials. In addition to\nvarying the size of ion channel clusters, living organisms may adapt the\ndensities of ion channels in order to optimally regulate the spontaneous\nspiking activity. The influence of channel block on the excitability of a\nmembrane patch of certain size is twofold: First, a variation of ion channel\ndensities primarily yields a change of the conductance level. Second, a\ndown-regulation of working ion channels always increases the channel noise.\nWhile the former effect dominates in the case of sodium channel block resulting\nin a reduced spiking activity, the latter enhances the generation of\nspontaneous action potentials in the case of a tailored potassium channel\nblocking. Moreover, by blocking some portion of either potassium or sodium ion\nchannels, it is possible to either increase or to decrease the regularity of\nthe spike train.",
"arxiv_id": "q-bio/0601013",
"authors": [
"Gerhard Schmid",
"Igor Goychuk",
"Peter Hanggi"
],
"categories": [
"q-bio.SC"
],
"doi": "10.1088/1478-3967/1/2/002",
"journal_ref": "PHYSICAL BIOLOGY 1, pp. 61-66 (2004)",
"title": "Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model",
"url": "https://arxiv.org/abs/q-bio/0601013"
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