dorsal/arxiv
View SchemaDirectionality of glioblastoma invasion in a 3d in vitro experiment
| Authors | A M Stein, D A Vader, T S Deisboeck, E A Chiocca, L M Sander, D A Weitz |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0610031 |
| URL | https://arxiv.org/abs/q-bio/0610031 |
Abstract
Glioblastoma is the most malignant form of brain cancer. It is extremely invasive; the mechanisms that govern invasion are not well understood. To better understand the process of invasion, we conducted an in vitro experiment in which a 3d tumour spheroid is implanted into a collagen gel. The paths of individual invasive cells were tracked. These cells were modeled as radially biased, persistent random walkers. The radial velocity bias was found to be 20 microns/hr on day one, but decayed significantly by day two. The cause of this bias is thought to be due to chemotactic factors and contact guidance along collagen fibers.
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"abstract": "Glioblastoma is the most malignant form of brain cancer. It is extremely\ninvasive; the mechanisms that govern invasion are not well understood. To\nbetter understand the process of invasion, we conducted an in vitro experiment\nin which a 3d tumour spheroid is implanted into a collagen gel. The paths of\nindividual invasive cells were tracked. These cells were modeled as radially\nbiased, persistent random walkers. The radial velocity bias was found to be 20\nmicrons/hr on day one, but decayed significantly by day two. The cause of this\nbias is thought to be due to chemotactic factors and contact guidance along\ncollagen fibers.",
"arxiv_id": "q-bio/0610031",
"authors": [
"A M Stein",
"D A Vader",
"T S Deisboeck",
"E A Chiocca",
"L M Sander",
"D A Weitz"
],
"categories": [
"q-bio.CB"
],
"title": "Directionality of glioblastoma invasion in a 3d in vitro experiment",
"url": "https://arxiv.org/abs/q-bio/0610031"
},
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