dorsal/arxiv
View SchemaGenetic Algorithms for the Imitation of Genomic Styles in Protein Backtranslation
| Authors | Andres Moreira |
|---|---|
| Categories | |
| ArXiv ID | physics/0304016 |
| URL | https://arxiv.org/abs/physics/0304016 |
Abstract
Several technological applications require the translation of a protein into a nucleic acid that codes for it (``backtranslation''). The degeneracy of the genetic code makes this translation ambiguous; moreover, not every translation is equally viable. The common answer to this problem is the imitation of the codon usage of the target species. Here we discuss several other features of coding sequences (``coding statistics'') that are relevant for the ``genomic style'' of different species. A genetic algorithm is then used to obtain backtranslations that mimic these styles, by minimizing the difference in the coding statistics. Possible improvements and applications are discussed.
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"abstract": "Several technological applications require the translation of a protein into\na nucleic acid that codes for it (``backtranslation\u0027\u0027). The degeneracy of the\ngenetic code makes this translation ambiguous; moreover, not every translation\nis equally viable. The common answer to this problem is the imitation of the\ncodon usage of the target species. Here we discuss several other features of\ncoding sequences (``coding statistics\u0027\u0027) that are relevant for the ``genomic\nstyle\u0027\u0027 of different species. A genetic algorithm is then used to obtain\nbacktranslations that mimic these styles, by minimizing the difference in the\ncoding statistics. Possible improvements and applications are discussed.",
"arxiv_id": "physics/0304016",
"authors": [
"Andres Moreira"
],
"categories": [
"physics.bio-ph",
"q-bio.QM"
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"title": "Genetic Algorithms for the Imitation of Genomic Styles in Protein Backtranslation",
"url": "https://arxiv.org/abs/physics/0304016"
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