{
  "annotation_id": "5059a056-fe92-4fa4-ad6d-318bf8baf23d",
  "date_created": "2026-03-02T18:00:36.384000Z",
  "date_modified": "2026-03-02T18:00:36.384000Z",
  "file_hash": "6a517091456dd4daf4329e3d0f58538162a9aa8920682b99c69ca35f9372f618",
  "private": false,
  "record": {
    "abstract": "In this letter we present the results of a simple model for intercellular\ncommunication via calcium oscillations, motivated in part by a recent\nexperimental study. The model describes two cells (a \"donor\" and \"sensor\")\nwhose intracellular dynamics involve a calcium-induced, calcium release\nprocess. The cells are coupled by assuming that the the input of the sensor\ncell is proportional to the output of the donor cell. As one varies the\nfrequency of calcium oscillations of the donor cell, the sensor cell passes\nthrough a sequence of N:M phase locked regimes and exhibits a \"Devil\u0027s\nstaircase\" behavior. Such a phase locked response has been seen experimentally\nin pulsatile stimulation of single cells. We also study a stochastic version of\nthe coupled two cell model. We find that phase locking holds for realistic\nchoices for the cell volume.",
    "arxiv_id": "physics/0111137",
    "authors": [
      "M. E. Gracheva",
      "J. D. Gunton"
    ],
    "categories": [
      "physics.bio-ph",
      "q-bio"
    ],
    "title": "Intercellular Communication Via Intracellular Calcium Oscillations",
    "url": "https://arxiv.org/abs/physics/0111137"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "d0985f26-d400-424c-b7c7-91ae3492cb03",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}