dorsal/arxiv
View SchemaModel for processive movement of dynein
| Authors | Ping Xie, Shuo-Xing Dou, Peng-Ye Wang |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0411023 |
| URL | https://arxiv.org/abs/q-bio/0411023 |
Abstract
A model for the processive movement of dynein is presented based on experimental observations available. In the model, the change from strong microtubule-binding to weak binding of dynein is determined naturally by the variation of the relative orientation between the two interacting surfaces of the stalk tip and the microtubule as the stalk rotates from the ADP.Vi-state orientation to the apo-state orientation. This means that the puzzling communication from the ATP binding site in the globular head to the MT-binding site in the tip of the stalk, which is prerequisite in the conventional model, is not required. Using the present model, the previous experimental results, such as (i) the step size of a dynein being an integer times of the period of the MT lattice, (ii) the dependence of the step size on load, i.e., the step size decreasing with the increase of load, and (iii) the stall force being proportional to [ATP] at low [ATP] and becoming saturated at high [ATP], are well explained.
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"date_created": "2026-03-02T18:01:32.282000Z",
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"abstract": "A model for the processive movement of dynein is presented based on\nexperimental observations available. In the model, the change from strong\nmicrotubule-binding to weak binding of dynein is determined naturally by the\nvariation of the relative orientation between the two interacting surfaces of\nthe stalk tip and the microtubule as the stalk rotates from the ADP.Vi-state\norientation to the apo-state orientation. This means that the puzzling\ncommunication from the ATP binding site in the globular head to the MT-binding\nsite in the tip of the stalk, which is prerequisite in the conventional model,\nis not required. Using the present model, the previous experimental results,\nsuch as (i) the step size of a dynein being an integer times of the period of\nthe MT lattice, (ii) the dependence of the step size on load, i.e., the step\nsize decreasing with the increase of load, and (iii) the stall force being\nproportional to [ATP] at low [ATP] and becoming saturated at high [ATP], are\nwell explained.",
"arxiv_id": "q-bio/0411023",
"authors": [
"Ping Xie",
"Shuo-Xing Dou",
"Peng-Ye Wang"
],
"categories": [
"q-bio.BM"
],
"title": "Model for processive movement of dynein",
"url": "https://arxiv.org/abs/q-bio/0411023"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "a14df04c-2768-4f4d-a307-9109be0c5ce9",
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"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
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