{
  "annotation_id": "4d9fb7f3-d951-46ce-9281-23ce9574800e",
  "date_created": "2026-03-02T18:01:28.597000Z",
  "date_modified": "2026-03-02T18:01:28.597000Z",
  "file_hash": "f266b74322f34ac79067205da2e5f94b062dce9a5c1a4a29f170deeabc75c444",
  "private": false,
  "record": {
    "abstract": "The immune system is a real-time example of an evolving system that navigates\nthe essentially infinite complexity of protein sequence space. How this system\nresponds to disease and vaccination is discussed. Of particular focus is the\ncase when vaccination leads to increased susceptibility to disease, a\nphenomenon termed original antigenic sin. A physical theory of protein\nevolution to explain limitations in the immune system response to vaccination\nand disease is discussed, and original antigenic sin is explained as stemming\nfrom localization of the immune system response in antibody sequence space.\nThis localization is a result of the roughness in sequence space of the evolved\nantibody affinity constant for antigen and is observed for diseases with high\nyear-to-year mutation rates, such as influenza.",
    "arxiv_id": "q-bio/0310019",
    "authors": [
      "Michael W. Deem"
    ],
    "categories": [
      "q-bio.CB",
      "cond-mat",
      "q-bio.PE"
    ],
    "title": "Complexity in the Immune System",
    "url": "https://arxiv.org/abs/q-bio/0310019"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "a8c88858-77da-41cb-b04e-73e9076968d6",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}