{
  "annotation_id": "4c84f09a-4f71-4840-adad-80944106e531",
  "date_created": "2026-03-02T18:01:35.735000Z",
  "date_modified": "2026-03-02T18:01:35.735000Z",
  "file_hash": "e43f1c2384e8c82f86da31384ac5c07418919baedaf1f66bb17b26d88e49d399",
  "private": false,
  "record": {
    "abstract": "Affinity maturation of antibodies during immune responses is achieved by\nmultiple rounds of somatic hypermutation and subsequent preferential selection\nof those B cells that express B cell receptors with improved binding\ncharacteristics for the antigen. The mechanism underlying B cell selection has\nnot yet been defined. By employing an agent-based model, we show that for\nphysiologically reasonable parameter values affinity maturation can neither be\ndriven by competition for binding sites nor antigen -- even in the presence of\ncompeting secreted antibodies. Within the tested mechanisms, only clonal\ncompetition for T cell help or a refractory time for the interaction of\ncentrocytes with follicular dendritic cells are found to enable affinity\nmaturation while generating the experimentally observed germinal center\ncharacteristics and tolerating large variations in the initial antigen density.",
    "arxiv_id": "q-bio/0611046",
    "authors": [
      "Michael Meyer-Hermann",
      "Philip K. Maini",
      "Dagmar Iber"
    ],
    "categories": [
      "q-bio.CB",
      "physics.bio-ph",
      "q-bio.TO"
    ],
    "journal_ref": "Math Med Biol 23 (2006) 255",
    "title": "An analysis of B cell selection mechanisms in germinal centers",
    "url": "https://arxiv.org/abs/q-bio/0611046"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "a463debf-705d-4fc0-b730-60ecb46d91fc",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}