dorsal/arxiv
View SchemaApproximating genealogies for partially linked neutral loci under a selective sweep
| Authors | P. Pfaffelhuber, A. Studeny |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0611029 |
| URL | https://arxiv.org/abs/q-bio/0611029 |
Abstract
Consider a genetic locus carrying a strongly beneficial allele which has recently fixed in a large population. As strongly beneficial alleles fix quickly, sequence diversity at partially linked neutral loci is reduced. This phenomenon is known as a selective sweep. The fixation of the beneficial allele not only affects sequence diversity at single neutral loci but also the joint allele distribution of several partially linked neutral loci. This distribution can be studied using the ancestral recombination graph for samples of partially linked neutral loci during the selective sweep. To approximate this graph, we extend recent work by Schweinsberg & Durrett 2005 and Etheridge, Pfaffelhuber & Wakolbinger 2006 using a marked Yule tree for the genealogy at a single neutral locus linked to a strongly beneficial one. We focus on joint genealogies at two partially linked neutral loci in the case of large selection coefficients \alpha and recombination rates \rho = O(\alpha/\log\alpha) between loci. Our approach leads to a full description of the genealogy with accuracy of O((\log \alpha)^{-2}) in probability. As an application, we derive the expectation of Lewontin's D as a measure for non-random association of alleles.
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"abstract": "Consider a genetic locus carrying a strongly beneficial allele which has\nrecently fixed in a large population. As strongly beneficial alleles fix\nquickly, sequence diversity at partially linked neutral loci is reduced. This\nphenomenon is known as a selective sweep. The fixation of the beneficial allele\nnot only affects sequence diversity at single neutral loci but also the joint\nallele distribution of several partially linked neutral loci. This distribution\ncan be studied using the ancestral recombination graph for samples of partially\nlinked neutral loci during the selective sweep. To approximate this graph, we\nextend recent work by Schweinsberg \u0026 Durrett 2005 and Etheridge, Pfaffelhuber \u0026\nWakolbinger 2006 using a marked Yule tree for the genealogy at a single neutral\nlocus linked to a strongly beneficial one. We focus on joint genealogies at two\npartially linked neutral loci in the case of large selection coefficients\n\\alpha and recombination rates \\rho = O(\\alpha/\\log\\alpha) between loci. Our\napproach leads to a full description of the genealogy with accuracy of O((\\log\n\\alpha)^{-2}) in probability. As an application, we derive the expectation of\nLewontin\u0027s D as a measure for non-random association of alleles.",
"arxiv_id": "q-bio/0611029",
"authors": [
"P. Pfaffelhuber",
"A. Studeny"
],
"categories": [
"q-bio.PE",
"math.PR"
],
"title": "Approximating genealogies for partially linked neutral loci under a selective sweep",
"url": "https://arxiv.org/abs/q-bio/0611029"
},
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