dorsal/arxiv
View SchemaRobustness and Evolvability of the B Cell Mutator Mechanism
| Authors | Patricia Theodosopoulos, Ted Theodosopoulos |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0506004 |
| URL | https://arxiv.org/abs/q-bio/0506004 |
Abstract
We present a model that considers the maturation of the antibody population following primary antigen presentation as a global optimization problem. The trade-off that emerges from our model describes the balance between the safety of mutations that lead to local improvements in affinity and the necessity of the system to undergo global reconfigurations in the antibody's shape in order to achieve its goals, in this example of fast-paced evolution. The parameter p which quantifies this trade-off appears to be itself both robust and evolvable. This parallels the rapidity and consistency of the optimization operating during the biologic response. In this paper, we explore the robust qualities and evolvability of this tunable control parameter, p.
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"date_created": "2026-03-02T18:01:32.280000Z",
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"abstract": "We present a model that considers the maturation of the antibody population\nfollowing primary antigen presentation as a global optimization problem. The\ntrade-off that emerges from our model describes the balance between the safety\nof mutations that lead to local improvements in affinity and the necessity of\nthe system to undergo global reconfigurations in the antibody\u0027s shape in order\nto achieve its goals, in this example of fast-paced evolution. The parameter p\nwhich quantifies this trade-off appears to be itself both robust and evolvable.\nThis parallels the rapidity and consistency of the optimization operating\nduring the biologic response. In this paper, we explore the robust qualities\nand evolvability of this tunable control parameter, p.",
"arxiv_id": "q-bio/0506004",
"authors": [
"Patricia Theodosopoulos",
"Ted Theodosopoulos"
],
"categories": [
"q-bio.QM",
"q-bio.PE"
],
"title": "Robustness and Evolvability of the B Cell Mutator Mechanism",
"url": "https://arxiv.org/abs/q-bio/0506004"
},
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"source": {
"execution_id": "4accb79d-d5d1-4fcf-a61c-37bd45558f3f",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
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