dorsal/arxiv
View SchemaThe influence of anesthetics, neurotransmitters and antibiotics on the relaxation processes in lipid membranes
| Authors | Heiko M. Seeger, Marie L. Gudmundsson, Thomas Heimburg |
|---|---|
| Categories | |
| ArXiv ID | physics/0703022 |
| URL | https://arxiv.org/abs/physics/0703022 |
| DOI | 10.1021/jp075346b |
| Journal | J. Phys. Chem. B 111 (2007) 13858-13866 |
Abstract
In the proximity of melting transitions of artificial and biological membranes fluctuations in enthalpy, area, volume and concentration are enhanced. This results in domain formation, changes of the elastic constants, changes in permeability and slowing down of relaxation processes. In this study we used pressure perturbation calorimetry to investigate the relaxation time scale after a jump into the melting transition regime of artificial lipid membranes. This time corresponds to the characteristic rate of domain growth. The studies were performed on single-component large unilamellar and multilamellar vesicle systems with and without the addition of small molecules such as general anesthetics, neurotransmitters and antibiotics. These drugs interact with membranes and affect melting points and profiles. In all systems we found that heat capacity and relaxation times are related to each other in a simple manner. The maximum relaxation time depends on the cooperativity of the heat capacity profile and decreases with a broadening of the transition. For this reason the influence of a drug on the time scale of domain formation processes can be understood on the basis of their influence on the heat capacity profile. This allows estimations of the time scale of domain formation processes in biological membranes.
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"abstract": "In the proximity of melting transitions of artificial and biological\nmembranes fluctuations in enthalpy, area, volume and concentration are\nenhanced. This results in domain formation, changes of the elastic constants,\nchanges in permeability and slowing down of relaxation processes. In this study\nwe used pressure perturbation calorimetry to investigate the relaxation time\nscale after a jump into the melting transition regime of artificial lipid\nmembranes. This time corresponds to the characteristic rate of domain growth.\nThe studies were performed on single-component large unilamellar and\nmultilamellar vesicle systems with and without the addition of small molecules\nsuch as general anesthetics, neurotransmitters and antibiotics. These drugs\ninteract with membranes and affect melting points and profiles. In all systems\nwe found that heat capacity and relaxation times are related to each other in a\nsimple manner. The maximum relaxation time depends on the cooperativity of the\nheat capacity profile and decreases with a broadening of the transition. For\nthis reason the influence of a drug on the time scale of domain formation\nprocesses can be understood on the basis of their influence on the heat\ncapacity profile. This allows estimations of the time scale of domain formation\nprocesses in biological membranes.",
"arxiv_id": "physics/0703022",
"authors": [
"Heiko M. Seeger",
"Marie L. Gudmundsson",
"Thomas Heimburg"
],
"categories": [
"physics.bio-ph"
],
"doi": "10.1021/jp075346b",
"journal_ref": "J. Phys. Chem. B 111 (2007) 13858-13866",
"title": "The influence of anesthetics, neurotransmitters and antibiotics on the relaxation processes in lipid membranes",
"url": "https://arxiv.org/abs/physics/0703022"
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