dorsal/arxiv
View SchemaDynamics of Acute Inflammation
| Authors | Rukmini Kumar, Gilles Clermont, Yoram Vodovotz, Carson Chow |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0404034 |
| URL | https://arxiv.org/abs/q-bio/0404034 |
Abstract
When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as Sepsis and can culminate in organ failure and death. We consider a three dimensional ordinary differential equation model of inflammation consisting of a pathogen, and two inflammatory mediators. The model reproduces the healthy outcome and diverse negative outcomes, depending on initial conditions and parameters.when key parameters are changed and suggest various therapeutic strategies. We suggest that the clinical condition of sepsis can arise from several distinct physiological states, each of which requires a different treatment approach. We analyze the various bifurcations between the different outcomes
{
"annotation_id": "48dfd7f0-d187-4ad4-858f-2cbd22772bd3",
"date_created": "2026-03-02T18:01:31.017000Z",
"date_modified": "2026-03-02T18:01:31.017000Z",
"file_hash": "7553f0e10e130b5f4bb1baea449139144951e8e90c48f4e17e4d66cdc6fed52e",
"private": false,
"record": {
"abstract": "When the body is infected, it mounts an acute inflammatory response to rid\nitself of the pathogens and restore health. Uncontrolled acute inflammation due\nto infection is defined clinically as Sepsis and can culminate in organ failure\nand death. We consider a three dimensional ordinary differential equation model\nof inflammation consisting of a pathogen, and two inflammatory mediators. The\nmodel reproduces the healthy outcome and diverse negative outcomes, depending\non initial conditions and parameters.when key parameters are changed and\nsuggest various therapeutic strategies. We suggest that the clinical condition\nof sepsis can arise from several distinct physiological states, each of which\nrequires a different treatment approach. We analyze the various bifurcations\nbetween the different outcomes",
"arxiv_id": "q-bio/0404034",
"authors": [
"Rukmini Kumar",
"Gilles Clermont",
"Yoram Vodovotz",
"Carson Chow"
],
"categories": [
"q-bio.TO"
],
"title": "Dynamics of Acute Inflammation",
"url": "https://arxiv.org/abs/q-bio/0404034"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "35db187b-6d18-4fcf-990c-9ad627f9260a",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}