dorsal/arxiv
View SchemaStructural information from multilamellar liposomes at full hydration: full q-range fitting with high quality X-ray data
| Authors | Georg Pabst, Michael Rappolt, Heinz Amenitsch, Peter Laggner |
|---|---|
| Categories | |
| ArXiv ID | physics/0002039 |
| URL | https://arxiv.org/abs/physics/0002039 |
| DOI | 10.1103/PhysRevE.62.4000 |
Abstract
We present a novel method for analyzing Small Angle X-ray Scattering data on multilamellar phospholipid bilayer systems at full hydration. The method utilizes a modified Caille' theory structure factor in combination with a Gaussian model representation of the electron density profile such that it accounts also for the diffuse scattering between Bragg peaks. Thus, the method can retrieve structural information even if only a few orders of diffraction are observed. We further introduce a new procedure to derive fundamental parameters, such as area per lipid, membrane thickness, and number of water molecules per lipid, directly from the electron density profile without the need of additional volumetric measurements. The theoretical apparatus is applied to experimental data on 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine liposome preparations.
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"abstract": "We present a novel method for analyzing Small Angle X-ray Scattering data on\nmultilamellar phospholipid bilayer systems at full hydration. The method\nutilizes a modified Caille\u0027 theory structure factor in combination with a\nGaussian model representation of the electron density profile such that it\naccounts also for the diffuse scattering between Bragg peaks. Thus, the method\ncan retrieve structural information even if only a few orders of diffraction\nare observed. We further introduce a new procedure to derive fundamental\nparameters, such as area per lipid, membrane thickness, and number of water\nmolecules per lipid, directly from the electron density profile without the\nneed of additional volumetric measurements. The theoretical apparatus is\napplied to experimental data on\n1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and\n1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine liposome preparations.",
"arxiv_id": "physics/0002039",
"authors": [
"Georg Pabst",
"Michael Rappolt",
"Heinz Amenitsch",
"Peter Laggner"
],
"categories": [
"physics.bio-ph"
],
"doi": "10.1103/PhysRevE.62.4000",
"title": "Structural information from multilamellar liposomes at full hydration: full q-range fitting with high quality X-ray data",
"url": "https://arxiv.org/abs/physics/0002039"
},
"schema_id": "dorsal/arxiv",
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