dorsal/arxiv
View SchemaGrowth Velocities of Branched Actin Networks
| Authors | A. E. Carlsson |
|---|---|
| Categories | |
| ArXiv ID | physics/0302088 |
| URL | https://arxiv.org/abs/physics/0302088 |
| DOI | 10.1016/S0006-3495(03)70018-6 |
Abstract
The growth of an actin network against an obstacle that stimulates branching locally is studied using several variants of a kinetic rate model based on the orientation-dependent number density of filaments. The model emphasizes the effects of branching and capping on the density of free filament ends. The variants differ in their treatment of side vs. end branching and dimensionality, and assume that new branches are generated by existing branches (autocatalytic behavior) or independently of existing branches (nucleation behavior). In autocatalytic models, the network growth velocity is rigorously independent of the opposing force exerted by the obstacle, and the network density is proportional to the force. The dependence of the growth velocity on the branching and capping rates is evaluated by a numerical solution of the rate equations. In side-branching models, the growth velocity drops gradually to zero with decreasing branching rate, while in end-branching models the drop is abrupt. As the capping rate goes to zero, it is found that the behavior of the velocity is sensitive to the thickness of the branching region. Experiments are proposed for using these results to shed light on the nature of the branching process.
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"abstract": "The growth of an actin network against an obstacle that stimulates branching\nlocally is studied using several variants of a kinetic rate model based on the\norientation-dependent number density of filaments. The model emphasizes the\neffects of branching and capping on the density of free filament ends. The\nvariants differ in their treatment of side vs. end branching and\ndimensionality, and assume that new branches are generated by existing branches\n(autocatalytic behavior) or independently of existing branches (nucleation\nbehavior). In autocatalytic models, the network growth velocity is rigorously\nindependent of the opposing force exerted by the obstacle, and the network\ndensity is proportional to the force. The dependence of the growth velocity on\nthe branching and capping rates is evaluated by a numerical solution of the\nrate equations. In side-branching models, the growth velocity drops gradually\nto zero with decreasing branching rate, while in end-branching models the drop\nis abrupt. As the capping rate goes to zero, it is found that the behavior of\nthe velocity is sensitive to the thickness of the branching region. Experiments\nare proposed for using these results to shed light on the nature of the\nbranching process.",
"arxiv_id": "physics/0302088",
"authors": [
"A. E. Carlsson"
],
"categories": [
"physics.bio-ph",
"cond-mat",
"q-bio"
],
"doi": "10.1016/S0006-3495(03)70018-6",
"title": "Growth Velocities of Branched Actin Networks",
"url": "https://arxiv.org/abs/physics/0302088"
},
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