{
  "annotation_id": "461607ce-03a2-4741-b6ca-0208c5d06374",
  "date_created": "2026-03-02T18:00:32.416000Z",
  "date_modified": "2026-03-02T18:00:32.416000Z",
  "file_hash": "456c12b94e374b0657846dc4dba29776856b0147b301e07f3ea05af4305d9e92",
  "private": false,
  "record": {
    "abstract": "The theory of stochastic transcription termination based on free-energy\ncompetition requires two or more reaction rates to be delicately balanced over\na wide range of physical conditions. A large body of work on glasses and large\nmolecules suggests that this should be impossible in such a large system in the\nabsence of a new organizing principle of matter. We review the experimental\nliterature of termination and find no evidence for such a principle but many\ntroubling inconsistencies, most notably anomalous memory effects. These suggest\nthat termination has a deterministic component and may conceivably be not\nstochastic at all. We find that a key experiment by Wilson and von Hippel\nallegedly refuting deterministic termination was an incorrectly analyzed\nregulatory effect of Mg2+ binding.",
    "arxiv_id": "physics/0009048",
    "authors": [
      "K. J. Harrington",
      "R. B. Laughlin",
      "S. Liang"
    ],
    "categories": [
      "physics.bio-ph",
      "cond-mat.soft",
      "q-bio"
    ],
    "doi": "10.1073/pnas.240431598",
    "title": "Balanced Branching in Transcription Termination",
    "url": "https://arxiv.org/abs/physics/0009048"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "e0affe87-2ae9-4740-8089-04e2dcb6d708",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}