{
  "annotation_id": "460da6b1-7a6b-4eec-bf75-b6e46cb47a95",
  "date_created": "2026-03-02T18:01:31.671000Z",
  "date_modified": "2026-03-02T18:01:31.671000Z",
  "file_hash": "a7b3a0bfaf0e9b7bbd8037bb238c0cb07920fe2a8b25bda89e70f8ecb570ebeb",
  "private": false,
  "record": {
    "abstract": "We address the controversial hot question concerning the validity of the\nloose-coupling versus the lever-arm models in the actomyosin dynamics by\nre-interpreting and extending the washboard potential model proposed by some of\nus in a previous paper. In the new theory, a loose-coupling mechanism co-exists\nwith the deterministic lever-arm model. The synergetic action of a random\ncomponent, originating from the harnessed thermal energy, and of the\npower-stroke generated by the lever-arm classical mechanism is seen to yield an\nexcellent fit of the set of data obtained in T. Yanagida\u0027s laboratory on the\nsliding of Myosin II heads on actin filaments under various load conditions.\nOur theoretical arguments are complemented by accurate numerical simulations,\nand the robustness of theory is tested via different combination of parameters\nand potential profiles.",
    "arxiv_id": "q-bio/0404011",
    "authors": [
      "A. Buonocore",
      "L. Caputo",
      "E. Pirozzi",
      "L. M. Ricciardi"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "title": "Lever-arm and Washboard-potential theories jointly account for Myosin II   dynamics",
    "url": "https://arxiv.org/abs/q-bio/0404011"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "7ece4e5b-d4da-439b-90d7-1bcb88838b68",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}