dorsal/arxiv
View SchemaStructure and function of negative feedback loops at the interface of genetic and metabolic networks
| Authors | Sandeep Krishna, Anna M. C. Andersson, Szabolcs Semsey, Kim Sneppen |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0604029 |
| URL | https://arxiv.org/abs/q-bio/0604029 |
| Journal | Nucleic Acids Res., 34: 2455 - 2462 (2006). |
Abstract
The molecular network in an organism consists of transcription/translation regulation, protein-protein interactions/modifications and a metabolic network, together forming a system that allows the cell to respond sensibly to the multiple signal molecules that exist in its environment. A key part of this overall system of molecular regulation is therefore the interface between the genetic and the metabolic network. A motif that occurs very often at this interface is a negative feedback loop used to regulate the level of the signal molecules. In this work we use mathematical models to investigate the steady state and dynamical behaviour of different negative feedback loops. We show, in particular, that feedback loops where the signal molecule does not cause the dissociation of the transcription factor from the DNA respond faster than loops where the molecule acts by sequestering transcription factors off the DNA. We use three examples, the bet, mer and lac systems in E. coli, to illustrate the behaviour of such feedback loops.
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"abstract": "The molecular network in an organism consists of transcription/translation\nregulation, protein-protein interactions/modifications and a metabolic network,\ntogether forming a system that allows the cell to respond sensibly to the\nmultiple signal molecules that exist in its environment. A key part of this\noverall system of molecular regulation is therefore the interface between the\ngenetic and the metabolic network. A motif that occurs very often at this\ninterface is a negative feedback loop used to regulate the level of the signal\nmolecules. In this work we use mathematical models to investigate the steady\nstate and dynamical behaviour of different negative feedback loops. We show, in\nparticular, that feedback loops where the signal molecule does not cause the\ndissociation of the transcription factor from the DNA respond faster than loops\nwhere the molecule acts by sequestering transcription factors off the DNA. We\nuse three examples, the bet, mer and lac systems in E. coli, to illustrate the\nbehaviour of such feedback loops.",
"arxiv_id": "q-bio/0604029",
"authors": [
"Sandeep Krishna",
"Anna M. C. Andersson",
"Szabolcs Semsey",
"Kim Sneppen"
],
"categories": [
"q-bio.MN",
"cond-mat.other"
],
"journal_ref": "Nucleic Acids Res., 34: 2455 - 2462 (2006).",
"title": "Structure and function of negative feedback loops at the interface of genetic and metabolic networks",
"url": "https://arxiv.org/abs/q-bio/0604029"
},
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