dorsal/arxiv
View SchemaYeast Protein Interactome Topology Provides Framework for Coordinated-Functionality
| Authors | Andre X. C. N. Valente, Michael E. Cusick |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0505006 |
| URL | https://arxiv.org/abs/q-bio/0505006 |
| DOI | 10.1093/nar/gkl325 |
| Journal | Nucleic Acids Research 34 (9) 2812-2819 (2006) |
Abstract
The architecture of the network of protein-protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and `Q-modularity'. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pair-wise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures.
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"abstract": "The architecture of the network of protein-protein physical interactions in\nSaccharomyces cerevisiae is exposed through the combination of two\ncomplementary theoretical network measures, betweenness centrality and\n`Q-modularity\u0027. The yeast interactome is characterized by well-defined\ntopological modules connected via a small number of inter-module protein\ninteractions. Should such topological inter-module connections turn out to\nconstitute a form of functional coordination between the modules, we speculate\nthat this coordination is occurring typically in a pair-wise fashion, rather\nthan by way of high-degree hub proteins responsible for coordinating multiple\nmodules. The unique non-hub-centric hierarchical organization of the\ninteractome is not reproduced by gene duplication-and-divergence stochastic\ngrowth models that disregard global selective pressures.",
"arxiv_id": "q-bio/0505006",
"authors": [
"Andre X. C. N. Valente",
"Michael E. Cusick"
],
"categories": [
"q-bio.MN",
"cond-mat.other",
"cond-mat.stat-mech",
"q-bio.OT"
],
"doi": "10.1093/nar/gkl325",
"journal_ref": "Nucleic Acids Research 34 (9) 2812-2819 (2006)",
"title": "Yeast Protein Interactome Topology Provides Framework for Coordinated-Functionality",
"url": "https://arxiv.org/abs/q-bio/0505006"
},
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