dorsal/arxiv
View SchemaInvasive advance of an advantageous mutation: nucleation theory
| Authors | Lauren O'Malley, James Basham, Joseph A. Yasi, G. Korniss, Andrew Allstadt, Tom Caraco |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0602023 |
| URL | https://arxiv.org/abs/q-bio/0602023 |
| DOI | 10.1016/j.tpb.2006.06.006 |
| Journal | Theoretical Population Biology, 70, 464-478 (2006). |
Abstract
For most organisms with viscous population structure, spatially localized growth drives the invasive advance of a favorable mutation. We model a two-allele competition where recurrent mutation introduces a genotype with a rate of local propagation exceeding the resident's rate. We capture ecologically important properties of the rare invader's stochastic dynamics by assuming discrete individuals and neighborhood interactions. To understand how individual-level processes may govern population patterns, we invoke the physical theory for nucleation of spatial systems. Nucleation theory discriminates between single-cluster and multi-cluster dynamics. A sufficiently low mutation rate, or a sufficiently small environment, generates single-cluster dynamics, an inherently stochastic process; a favorable mutation advances only if the invader cluster reaches a critical radius. For this mode of invasion we identify the probability distribution of waiting times until the favored allele advances to competitive dominance, and we ask how the critical cluster size varies as propagation or mortality rates vary. Increasing the mutation rate or system size generates multi-cluster invasion, where spatial averaging produces nearly deterministic global dynamics. For this process, an analytical approximation from nucleation theory, called Avrami's Law, describes the time-dependent behavior of the genotype densities with remarkable accuracy.
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"abstract": "For most organisms with viscous population structure, spatially localized\ngrowth drives the invasive advance of a favorable mutation. We model a\ntwo-allele competition where recurrent mutation introduces a genotype with a\nrate of local propagation exceeding the resident\u0027s rate. We capture\necologically important properties of the rare invader\u0027s stochastic dynamics by\nassuming discrete individuals and neighborhood interactions. To understand how\nindividual-level processes may govern population patterns, we invoke the\nphysical theory for nucleation of spatial systems. Nucleation theory\ndiscriminates between single-cluster and multi-cluster dynamics. A sufficiently\nlow mutation rate, or a sufficiently small environment, generates\nsingle-cluster dynamics, an inherently stochastic process; a favorable mutation\nadvances only if the invader cluster reaches a critical radius. For this mode\nof invasion we identify the probability distribution of waiting times until the\nfavored allele advances to competitive dominance, and we ask how the critical\ncluster size varies as propagation or mortality rates vary. Increasing the\nmutation rate or system size generates multi-cluster invasion, where spatial\naveraging produces nearly deterministic global dynamics. For this process, an\nanalytical approximation from nucleation theory, called Avrami\u0027s Law, describes\nthe time-dependent behavior of the genotype densities with remarkable accuracy.",
"arxiv_id": "q-bio/0602023",
"authors": [
"Lauren O\u0027Malley",
"James Basham",
"Joseph A. Yasi",
"G. Korniss",
"Andrew Allstadt",
"Tom Caraco"
],
"categories": [
"q-bio.PE",
"cond-mat.stat-mech"
],
"doi": "10.1016/j.tpb.2006.06.006",
"journal_ref": "Theoretical Population Biology, 70, 464-478 (2006).",
"title": "Invasive advance of an advantageous mutation: nucleation theory",
"url": "https://arxiv.org/abs/q-bio/0602023"
},
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