dorsal/arxiv
View SchemaModel evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics
| Authors | Lutz Brusch, Gianaurelio Cuniberti, Martin Bertau |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0404036 |
| URL | https://arxiv.org/abs/q-bio/0404036 |
| DOI | 10.1016/j.bpc.2003.12.004 |
| Journal | Biophysical Chemistry 109, 413-426 (2004) |
Abstract
Anaerobic glycolysis in yeast perturbed by the reduction of xenobiotic ketones is studied numerically in two models which possess the same topology but different levels of complexity. By comparing both models' predictions for concentrations and fluxes as well as steady or oscillatory temporal behavior we answer the question what phenomena require what kind of minimum model abstraction. While mean concentrations and fluxes are predicted in agreement by both models we observe different domains of oscillatory behavior in parameter space. Generic properties of the glycolytic response to ketones are discussed.
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"abstract": "Anaerobic glycolysis in yeast perturbed by the reduction of xenobiotic\nketones is studied numerically in two models which possess the same topology\nbut different levels of complexity. By comparing both models\u0027 predictions for\nconcentrations and fluxes as well as steady or oscillatory temporal behavior we\nanswer the question what phenomena require what kind of minimum model\nabstraction. While mean concentrations and fluxes are predicted in agreement by\nboth models we observe different domains of oscillatory behavior in parameter\nspace. Generic properties of the glycolytic response to ketones are discussed.",
"arxiv_id": "q-bio/0404036",
"authors": [
"Lutz Brusch",
"Gianaurelio Cuniberti",
"Martin Bertau"
],
"categories": [
"q-bio.MN",
"q-bio.QM"
],
"doi": "10.1016/j.bpc.2003.12.004",
"journal_ref": "Biophysical Chemistry 109, 413-426 (2004)",
"title": "Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics",
"url": "https://arxiv.org/abs/q-bio/0404036"
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