{
  "annotation_id": "43a8b6f6-ff89-47ba-89f4-c793993e204f",
  "date_created": "2026-03-02T18:01:31.821000Z",
  "date_modified": "2026-03-02T18:01:31.821000Z",
  "file_hash": "1507ae693cd9950840403dc13486149968a04388beceed9fd0b8feca600e424f",
  "private": false,
  "record": {
    "abstract": "A simplified model for the closed circular DNA (ccDNA) is proposed to\ndescribe some specific features of the helix-coil transition in such molecule.\nThe Hamiltonian of ccDNA is related to the one introduced earlier for the\nlinear DNA. The basic assumption is that the reduced energy of the hydrogen\nbond is not constant through the transition process but depends effectively on\nthe fraction of already broken bonds. A transformation formula is obtained\nwhich relates the temperature of ccDNA at a given degree of helicity during the\ntransition to the temperature of the corresponding linear chain at the same\ndegree of helicity. The formula provides a simple method to calculate the\nmelting curve for the ccDNA from the experimental melting curve of the linear\nDNA with the same nucleotide sequence.",
    "arxiv_id": "q-bio/0401021",
    "authors": [
      "V. F. Morozov",
      "Shura Hayryan",
      "E. Sh. Mamasakhlisov",
      "A. V. Grigoryan",
      "A. V. Badasyan",
      "Chin-Kun Hu"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "doi": "10.1016/j.physa.2004.09.037",
    "title": "Helix-coil Transition in Closed Circular DNA",
    "url": "https://arxiv.org/abs/q-bio/0401021"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "19ba3b5d-7c06-4d2e-80ae-199511cd054f",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}