dorsal/arxiv
View SchemaRobust formation of morphogen gradients
| Authors | T. Bollenbach, K. Kruse, P. Pantazis, M. González-Gaitán, F. Jülicher |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0412014 |
| URL | https://arxiv.org/abs/q-bio/0412014 |
| DOI | 10.1103/PhysRevLett.94.018103 |
| Journal | Physical Review Letters 94, 018103 (2005) |
Abstract
We discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from binding of ligands to receptors on the cell surface, incorporation into the cell and subsequent externalization. Starting from a microscopic model, we derive effective transport equations. We show that, in contrast to morphogen transport by extracellular diffusion, transcytosis leads to robust ligand profiles which are insensitive to the rate of ligand production.
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"abstract": "We discuss the formation of graded morphogen profiles in a cell layer by\nnonlinear transport phenomena, important for patterning developing organisms.\nWe focus on a process termed transcytosis, where morphogen transport results\nfrom binding of ligands to receptors on the cell surface, incorporation into\nthe cell and subsequent externalization. Starting from a microscopic model, we\nderive effective transport equations. We show that, in contrast to morphogen\ntransport by extracellular diffusion, transcytosis leads to robust ligand\nprofiles which are insensitive to the rate of ligand production.",
"arxiv_id": "q-bio/0412014",
"authors": [
"T. Bollenbach",
"K. Kruse",
"P. Pantazis",
"M. Gonz\u00e1lez-Gait\u00e1n",
"F. J\u00fclicher"
],
"categories": [
"q-bio.OT",
"physics.bio-ph"
],
"doi": "10.1103/PhysRevLett.94.018103",
"journal_ref": "Physical Review Letters 94, 018103 (2005)",
"title": "Robust formation of morphogen gradients",
"url": "https://arxiv.org/abs/q-bio/0412014"
},
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