dorsal/arxiv
View SchemaSequence sensitivity of breathing dynamics in heteropolymer DNA
| Authors | Tobias Ambjornsson, Suman K. Banik, Oleg Krichevsky, Ralf Metzler |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0608036 |
| URL | https://arxiv.org/abs/q-bio/0608036 |
| DOI | 10.1103/PhysRevLett.97.128105 |
Abstract
We study the fluctuation dynamics of localized denaturation bubbles in heteropolymer DNA with a master equation and complementary stochastic simulation based on novel DNA stability data. A significant dependence of opening probability and waiting time between bubble events on the local DNA sequence is revealed and quantified for a biological sequence of the T7 bacteriophage. Quantitative agreement with data from fluorescence correlation spectroscopy (FCS) is demonstrated.
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"abstract": "We study the fluctuation dynamics of localized denaturation bubbles in\nheteropolymer DNA with a master equation and complementary stochastic\nsimulation based on novel DNA stability data. A significant dependence of\nopening probability and waiting time between bubble events on the local DNA\nsequence is revealed and quantified for a biological sequence of the T7\nbacteriophage. Quantitative agreement with data from fluorescence correlation\nspectroscopy (FCS) is demonstrated.",
"arxiv_id": "q-bio/0608036",
"authors": [
"Tobias Ambjornsson",
"Suman K. Banik",
"Oleg Krichevsky",
"Ralf Metzler"
],
"categories": [
"q-bio.BM",
"cond-mat.stat-mech"
],
"doi": "10.1103/PhysRevLett.97.128105",
"title": "Sequence sensitivity of breathing dynamics in heteropolymer DNA",
"url": "https://arxiv.org/abs/q-bio/0608036"
},
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