dorsal/arxiv
View SchemaMonte Carlo simulations of the inside-intron recombination
| Authors | Stanislaw Cebrat, Andrzej Pekalski, Fabian Scharf |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0511010 |
| URL | https://arxiv.org/abs/q-bio/0511010 |
| DOI | 10.1142/S0129183106008984 |
Abstract
Biological genomes are divided into coding and non-coding regions. Introns are non-coding parts within genes, while the remaining non-coding parts are intergenic sequences. To study the evolutionary significance of recombination inside introns we have used two models based on the Monte Carlo method. In our computer simulations we have implemented the internal structure of genes by declaring the probability of recombination between exons. One situation when inside-intron recombination is advantageous is recovering functional genes by combining proper exons dispersed in the genetic pool of the population after a long period without selection for the function of the gene. Populations have to pass through the bottleneck, then. These events are rather rare and we have expected that there should be other phenomena giving profits from the inside-intron recombination. In fact we have found that inside-intron recombination is advantageous only in the case when after recombination, besides the recombinant forms, parental haplotypes are available and selection is set already on gametes.
{
"annotation_id": "41a3e83e-c6be-4ff5-9b10-5e0251a2c923",
"date_created": "2026-03-02T18:01:34.860000Z",
"date_modified": "2026-03-02T18:01:34.860000Z",
"file_hash": "486cac42725abb96030c8b42c1dca7f3b6c57cb1061cc9ec3b45ec6a93a5d1cc",
"private": false,
"record": {
"abstract": "Biological genomes are divided into coding and non-coding regions. Introns\nare non-coding parts within genes, while the remaining non-coding parts are\nintergenic sequences. To study the evolutionary significance of recombination\ninside introns we have used two models based on the Monte Carlo method. In our\ncomputer simulations we have implemented the internal structure of genes by\ndeclaring the probability of recombination between exons. One situation when\ninside-intron recombination is advantageous is recovering functional genes by\ncombining proper exons dispersed in the genetic pool of the population after a\nlong period without selection for the function of the gene. Populations have to\npass through the bottleneck, then. These events are rather rare and we have\nexpected that there should be other phenomena giving profits from the\ninside-intron recombination. In fact we have found that inside-intron\nrecombination is advantageous only in the case when after recombination,\nbesides the recombinant forms, parental haplotypes are available and selection\nis set already on gametes.",
"arxiv_id": "q-bio/0511010",
"authors": [
"Stanislaw Cebrat",
"Andrzej Pekalski",
"Fabian Scharf"
],
"categories": [
"q-bio.PE"
],
"doi": "10.1142/S0129183106008984",
"title": "Monte Carlo simulations of the inside-intron recombination",
"url": "https://arxiv.org/abs/q-bio/0511010"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "1e5edc97-b808-4add-885a-fd7e364efafa",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}