{
  "annotation_id": "3ffcec60-cfd3-4b2d-a731-823552b2ebce",
  "date_created": "2026-03-02T18:01:28.606000Z",
  "date_modified": "2026-03-02T18:01:28.606000Z",
  "file_hash": "6f12f300c6e85c2c39c51533cde1f7a0e370b627b6c152b11a20b9a6d514e9d6",
  "private": false,
  "record": {
    "abstract": "Analytic estimates for the forces and free energy generated by bilayer\ndeformation reveal a compelling and intuitive model for MscL channel gating\nanalogous to the nucleation of a second phase. We argue that the competition\nbetween hydrophobic mismatch and tension results in a surprisingly rich story\nwhich can provide both a quantitative comparison to measurements of opening\ntension for MscL when reconstituted in bilayers of different thickness and\nqualitative insights into the function of the MscL channel and other\ntransmembrane proteins.",
    "arxiv_id": "q-bio/0311010",
    "authors": [
      "Paul Wiggins",
      "Rob Phillips"
    ],
    "categories": [
      "q-bio.BM"
    ],
    "doi": "10.1073/pnas.0307804101",
    "title": "Analytic models for mechanotransduction: gating a mechanosensitive   channel",
    "url": "https://arxiv.org/abs/q-bio/0311010"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "169d1530-27f9-411f-9dc1-4bc0ee68bfd1",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}