{
  "annotation_id": "3fb7b67c-4cb0-407a-9f8d-9f840b3c1809",
  "date_created": "2026-03-02T18:01:28.773000Z",
  "date_modified": "2026-03-02T18:01:28.773000Z",
  "file_hash": "815ce20362bcb1374181cedd308b5289ed97a8e3ac7d808dc97177807cf6baf0",
  "private": false,
  "record": {
    "abstract": "We have performed a statistical analysis of the spatial distribution of\noperons in the transcriptional regulation network of Escherichia coli. The\nanalysis reveals that operons that regulate each other and operons that are\ncoregulated tend to lie next to each other on the genome. Moreover, these pairs\nof operons tend to be transcribed in diverging directions. This spatial\narrangement of operons allows the upstream regulatory regions to interfere with\neach other. This affords additional regulatory control, as illustrated by a\nmean-field analysis of a feed-forward loop. Our results suggest that regulatory\ncontrol can provide a selection pressure that drives operons together in the\ncourse of evolution.",
    "arxiv_id": "q-bio/0310029",
    "authors": [
      "P. B. Warren",
      "P. R. ten Wolde"
    ],
    "categories": [
      "q-bio.MN",
      "q-bio.GN"
    ],
    "title": "Statistical analysis of the spatial distribution of operons in the   transcriptional regulation network of Escherichia coli",
    "url": "https://arxiv.org/abs/q-bio/0310029"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "e411461b-15b9-43ed-83bb-6260348a9ff3",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}