dorsal/arxiv
View SchemaCFinder: Locating cliques and overlapping modules in biological networks
| Authors | Balazs Adamcsek, Gergely Palla, Illes J. Farkas, Imre Derenyi, Tamas Vicsek |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0602004 |
| URL | https://arxiv.org/abs/q-bio/0602004 |
| DOI | 10.1093/bioinformatics/btl039 |
| Journal | Bioinformatics 22, 1021-1023 (2006) |
Abstract
Summary: Most cellular tasks are performed not by individual proteins, but by groups of functionally associated proteins, often referred to as modules. In a protein assocation network modules appear as groups of densely interconnected nodes, also called communities or clusters. These modules often overlap with each other and form a network of their own, in which nodes (links) represent the modules (overlaps). We introduce CFinder, a fast program locating and visualizing overlapping, densely interconnected groups of nodes in undirected graphs, and allowing the user to easily navigate between the original graph and the web of these groups. We show that in gene (protein) association networks CFinder can be used to predict the function(s) of a single protein and to discover novel modules. CFinder is also very efficient for locating the cliques of large sparse graphs. Availability: CFinder (for Windows, Linux, and Macintosh) and its manual can be downloaded from http://angel.elte.hu/clustering. Contact: cfinder@angel.elte.hu
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"abstract": "Summary: Most cellular tasks are performed not by individual proteins, but by\ngroups of functionally associated proteins, often referred to as modules. In a\nprotein assocation network modules appear as groups of densely interconnected\nnodes, also called communities or clusters. These modules often overlap with\neach other and form a network of their own, in which nodes (links) represent\nthe modules (overlaps). We introduce CFinder, a fast program locating and\nvisualizing overlapping, densely interconnected groups of nodes in undirected\ngraphs, and allowing the user to easily navigate between the original graph and\nthe web of these groups. We show that in gene (protein) association networks\nCFinder can be used to predict the function(s) of a single protein and to\ndiscover novel modules. CFinder is also very efficient for locating the cliques\nof large sparse graphs.\n Availability: CFinder (for Windows, Linux, and Macintosh) and its manual can\nbe downloaded from http://angel.elte.hu/clustering.\n Contact: cfinder@angel.elte.hu",
"arxiv_id": "q-bio/0602004",
"authors": [
"Balazs Adamcsek",
"Gergely Palla",
"Illes J. Farkas",
"Imre Derenyi",
"Tamas Vicsek"
],
"categories": [
"q-bio.MN",
"q-bio.GN"
],
"doi": "10.1093/bioinformatics/btl039",
"journal_ref": "Bioinformatics 22, 1021-1023 (2006)",
"title": "CFinder: Locating cliques and overlapping modules in biological networks",
"url": "https://arxiv.org/abs/q-bio/0602004"
},
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