dorsal/arxiv
View SchemaRole of Polymer Loops in DNA Replication
| Authors | Suckjoon Jun, John Bechhoefer |
|---|---|
| Categories | |
| ArXiv ID | physics/0306156 |
| URL | https://arxiv.org/abs/physics/0306156 |
| Journal | Physics in Canada vol. 59. no. 2, pp. 85-92 (2003) |
Abstract
Loop formation in long molecules occurs many places in nature, from solutions of carbon nanotubes to polymers inside a cell. In this article, we review theoretical studies of the static and dynamic properties of polymer loops. For example, long polymers must search many configurations to find a "target" binding site, while short polymers are stiff and resist bending. In between, there is an optimal loop size, which balances the entropy of long loops against the energetic cost of short loops. We show that such simple pictures of loop formation can explain several long-standing observations in DNA replication, quantitatively.
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"abstract": "Loop formation in long molecules occurs many places in nature, from solutions\nof carbon nanotubes to polymers inside a cell. In this article, we review\ntheoretical studies of the static and dynamic properties of polymer loops. For\nexample, long polymers must search many configurations to find a \"target\"\nbinding site, while short polymers are stiff and resist bending. In between,\nthere is an optimal loop size, which balances the entropy of long loops against\nthe energetic cost of short loops. We show that such simple pictures of loop\nformation can explain several long-standing observations in DNA replication,\nquantitatively.",
"arxiv_id": "physics/0306156",
"authors": [
"Suckjoon Jun",
"John Bechhoefer"
],
"categories": [
"physics.bio-ph",
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],
"journal_ref": "Physics in Canada vol. 59. no. 2, pp. 85-92 (2003)",
"title": "Role of Polymer Loops in DNA Replication",
"url": "https://arxiv.org/abs/physics/0306156"
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