dorsal/arxiv
View SchemaBioinformatics analysis of experimentally determined protein complexes in the yeast, S. cerevisiae
| Authors | Zoltan Dezso, Zoltan N. Oltvai, Albert-Laszlo Barabasi |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0310012 |
| URL | https://arxiv.org/abs/q-bio/0310012 |
Abstract
Many important cellular functions are implemented by protein complexes that act as sophisticated molecular machines of varying size and temporal stability. Here we demonstrate quantitatively that protein complexes in the yeast, Saccharomyces cerevisiae, are comprised of a core in which subunits are highly coexpressed, display the same deletion phenotype (essential or non-essential) and share identical functional classification and cellular localization. This core is surrounded by a functionally mixed group of proteins, which likely represent short-lived- or spurious attachments. The results allow us to define the deletion phenotype and cellular task of most known complexes, and to identify with high confidence the biochemical role of hundreds of proteins with yet unassigned functionality.
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"date_created": "2026-03-02T18:01:28.594000Z",
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"abstract": "Many important cellular functions are implemented by protein complexes that\nact as sophisticated molecular machines of varying size and temporal stability.\nHere we demonstrate quantitatively that protein complexes in the yeast,\nSaccharomyces cerevisiae, are comprised of a core in which subunits are highly\ncoexpressed, display the same deletion phenotype (essential or non-essential)\nand share identical functional classification and cellular localization. This\ncore is surrounded by a functionally mixed group of proteins, which likely\nrepresent short-lived- or spurious attachments. The results allow us to define\nthe deletion phenotype and cellular task of most known complexes, and to\nidentify with high confidence the biochemical role of hundreds of proteins with\nyet unassigned functionality.",
"arxiv_id": "q-bio/0310012",
"authors": [
"Zoltan Dezso",
"Zoltan N. Oltvai",
"Albert-Laszlo Barabasi"
],
"categories": [
"q-bio.MN",
"cond-mat",
"q-bio.GN"
],
"title": "Bioinformatics analysis of experimentally determined protein complexes in the yeast, S. cerevisiae",
"url": "https://arxiv.org/abs/q-bio/0310012"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "7037fffa-d2d4-4077-8052-47df9e4fb4c7",
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"type": "Model",
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