{
  "annotation_id": "3d66acac-ecc8-4d18-b13a-2fd4506a5a83",
  "date_created": "2026-03-02T18:01:17.639000Z",
  "date_modified": "2026-03-02T18:01:17.639000Z",
  "file_hash": "7b90998e03debca845ad6ab478c641bed945602fd45cd1af934529edab3fcb57",
  "private": false,
  "record": {
    "abstract": "A mathematical model of genome degradation is proposed that takes into\naccount a variable rate of mutation and increasing number of cells in a\ndeveloping human organism. The model explains known properties of cancer\ndevelopment, in particular, a synergism between different mutagens and an\nincreased probability of cancer in the early years of life. An iteration\nequation is suggested that uses only a few model parameters and describes basic\nregularities observed in cancer onset. In the model context, relatively small\nchronic variations in the intracellular content of free radicals may markedly\naffect the probability of a cell to become a cancer cell. On the other hand,\nmagnetic nanoparticles are shown to be an endogenous source of chronic magnetic\nexposure that increases the local concentration of free radicals. An enhanced\nlevel of leukaemia in early childhood is assumed to originate from magnetic\nnanoparticles located in hematopoietic stem cells.",
    "arxiv_id": "physics/0701202",
    "authors": [
      "V. N. Binhi"
    ],
    "categories": [
      "physics.bio-ph"
    ],
    "title": "A mathematical model of DNA degradation: Possible role of magnetic   nanoparticles",
    "url": "https://arxiv.org/abs/physics/0701202"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "5eae3fde-950f-442d-b3a8-3321813de709",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}