dorsal/arxiv
View SchemaHow Noise and Coupling Induce Bursting Action Potentials in Pancreatic beta-cells
| Authors | J. Jo, H. Kang, M. Y. Choi, D. S. Koh |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0509004 |
| URL | https://arxiv.org/abs/q-bio/0509004 |
| DOI | 10.1529/biophysj.104.053181 |
| Journal | published in Biophysical Journal 89:1534-1542 (2005) |
Abstract
Unlike isolated beta-cells, which usually produce continuous spikes or fast and irregular bursts, electrically coupled beta-cells are apt to exhibit robust bursting action potentials. We consider the noise induced by thermal fluctuations as well as that by channel gating stochasticity and examine its effects on the action potential behavior of the beta-cell model. It is observed numerically that such noise in general helps single cells to produce a variety of electrical activities. In addition, we also probe coupling via gap junctions between neighboring cells,with heterogeneity induced by noise, to find that it enhances regular bursts.
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"abstract": "Unlike isolated beta-cells, which usually produce continuous spikes or fast\nand irregular bursts, electrically coupled beta-cells are apt to exhibit robust\nbursting action potentials. We consider the noise induced by thermal\nfluctuations as well as that by channel gating stochasticity and examine its\neffects on the action potential behavior of the beta-cell model. It is observed\nnumerically that such noise in general helps single cells to produce a variety\nof electrical activities. In addition, we also probe coupling via gap junctions\nbetween neighboring cells,with heterogeneity induced by noise, to find that it\nenhances regular bursts.",
"arxiv_id": "q-bio/0509004",
"authors": [
"J. Jo",
"H. Kang",
"M. Y. Choi",
"D. S. Koh"
],
"categories": [
"q-bio.CB",
"physics.bio-ph"
],
"doi": "10.1529/biophysj.104.053181",
"journal_ref": "published in Biophysical Journal 89:1534-1542 (2005)",
"title": "How Noise and Coupling Induce Bursting Action Potentials in Pancreatic beta-cells",
"url": "https://arxiv.org/abs/q-bio/0509004"
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