dorsal/arxiv
View SchemaFluctuation-Driven Molecular Transport in an Asymmetric Membrane Channel
| Authors | Ioan Kosztin, Klaus Schulten |
|---|---|
| Categories | |
| ArXiv ID | physics/0410254 |
| URL | https://arxiv.org/abs/physics/0410254 |
| DOI | 10.1103/PhysRevLett.93.238102 |
| Journal | Phys. Rev. Lett. 93, 238102 (2004) |
Abstract
Channel proteins, that selectively conduct molecules across cell membranes, often exhibit an asymmetric structure. By means of a stochastic model, we argue that channel asymmetry in the presence of non-equilibrium fluctuations, fueled by the cell's metabolism as observed recently, can dramatically influence the transport through such channels by a ratchet-like mechanism. For an aquaglyceroporin that conducts water and glycerol we show that a previously determined asymmetric glycerol potential leads to enhanced inward transport of glycerol, but for unfavorably high glycerol concentrations also to enhanced outward transport that protects a cell against poisoning.
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"abstract": "Channel proteins, that selectively conduct molecules across cell membranes,\noften exhibit an asymmetric structure. By means of a stochastic model, we argue\nthat channel asymmetry in the presence of non-equilibrium fluctuations, fueled\nby the cell\u0027s metabolism as observed recently, can dramatically influence the\ntransport through such channels by a ratchet-like mechanism. For an\naquaglyceroporin that conducts water and glycerol we show that a previously\ndetermined asymmetric glycerol potential leads to enhanced inward transport of\nglycerol, but for unfavorably high glycerol concentrations also to enhanced\noutward transport that protects a cell against poisoning.",
"arxiv_id": "physics/0410254",
"authors": [
"Ioan Kosztin",
"Klaus Schulten"
],
"categories": [
"physics.bio-ph",
"cond-mat.stat-mech",
"q-bio.BM"
],
"doi": "10.1103/PhysRevLett.93.238102",
"journal_ref": "Phys. Rev. Lett. 93, 238102 (2004)",
"title": "Fluctuation-Driven Molecular Transport in an Asymmetric Membrane Channel",
"url": "https://arxiv.org/abs/physics/0410254"
},
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