{
  "annotation_id": "3b7d011b-05c1-41cc-897c-84c8d4a831b3",
  "date_created": "2026-03-02T18:01:35.336000Z",
  "date_modified": "2026-03-02T18:01:35.336000Z",
  "file_hash": "6f3979e7bc973b40e94680ba2e742c0d295f582eea56a05bc9a67e10d5084571",
  "private": false,
  "record": {
    "abstract": "We present a general theoretical framework to discuss mechanisms of morphogen\ntransport and gradient formation in a cell layer. Trafficking events on the\ncellular scale lead to transport on larger scales. We discuss in particular the\ncase of transcytosis where morphogens undergo repeated rounds of\ninternalization into cells and recycling. Based on a description on the\ncellular scale, we derive effective nonlinear transport equations in one and\ntwo dimensions which are valid on larger scales. We derive analytic expressions\nfor the concentration dependence of the effective diffusion coefficient and the\neffective degradation rate. We discuss the effects of a directional bias on\nmorphogen transport and those of the coupling of the morphogen and receptor\nkinetics. Furthermore, we discuss general properties of cellular transport\nprocesses such as the robustness of gradients and relate our results to recent\nexperiments on the morphogen Decapentaplegic (Dpp) that acts in the fruit fly\nDrosophila.",
    "arxiv_id": "q-bio/0609011",
    "authors": [
      "T. Bollenbach",
      "K. Kruse",
      "P. Pantazis",
      "M. Gonzalez-Gaitan",
      "F. Julicher"
    ],
    "categories": [
      "q-bio.OT",
      "physics.bio-ph"
    ],
    "doi": "10.1103/PhysRevE.75.011901",
    "title": "Morphogen Transport in Epithelia",
    "url": "https://arxiv.org/abs/q-bio/0609011"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "b390066d-d541-40ca-bf4e-db4209a21e5a",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}