dorsal/arxiv
View SchemaHuman cancers over express genes that are specific to a variety of normal human tissues
| Authors | Joseph Lotem, Dvir Netanely, Eytan Domany, Leo Sachs |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0511021 |
| URL | https://arxiv.org/abs/q-bio/0511021 |
| DOI | 10.1073/pnas.0509360102 |
Abstract
We have analyzed gene expression data from 3 different kinds of samples: normal human tissues, human cancer cell lines and leukemic cells from lymphoid and myeloid leukemia pediatric patients. We have searched for genes that are over expressed in human cancer and also show specific patterns of tissue-dependent expression in normal tissues. Using the expression data of the normal tissues we identified 4346 genes with a high variability of expression, and clustered these genes according to their relative expression level. Of 91 stable clusters obtained, 24 clusters included genes preferentially expressed either only in hematopoietic tissues or in hematopoietic and 1-2 other tissues; 28 clusters included genes preferentially expressed in various non-hematopoietic tissues such as neuronal, testis, liver, kidney, muscle, lung, pancreas and placenta. Analysis of the expression levels of these 2 groups of genes in the human cancer cell lines and leukemias, identified genes that were highly expressed in cancer cells but not in their normal counterparts, and were thus over expressed in the cancers. The different cancer cell lines and leukemias varied in the number and identity of these over expressed genes. The results indicate that many genes that are over expressed in human cancer cells are specific to a variety of normal tissues, including normal tissues other than those from which the cancer originated. It is suggested that this general property of cancer cells plays a major role in determining the behavior of the cancers, including their metastatic potential.
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"abstract": "We have analyzed gene expression data from 3 different kinds of samples:\nnormal human tissues, human cancer cell lines and leukemic cells from lymphoid\nand myeloid leukemia pediatric patients. We have searched for genes that are\nover expressed in human cancer and also show specific patterns of\ntissue-dependent expression in normal tissues. Using the expression data of the\nnormal tissues we identified 4346 genes with a high variability of expression,\nand clustered these genes according to their relative expression level. Of 91\nstable clusters obtained, 24 clusters included genes preferentially expressed\neither only in hematopoietic tissues or in hematopoietic and 1-2 other tissues;\n28 clusters included genes preferentially expressed in various\nnon-hematopoietic tissues such as neuronal, testis, liver, kidney, muscle,\nlung, pancreas and placenta. Analysis of the expression levels of these 2\ngroups of genes in the human cancer cell lines and leukemias, identified genes\nthat were highly expressed in cancer cells but not in their normal\ncounterparts, and were thus over expressed in the cancers. The different cancer\ncell lines and leukemias varied in the number and identity of these over\nexpressed genes. The results indicate that many genes that are over expressed\nin human cancer cells are specific to a variety of normal tissues, including\nnormal tissues other than those from which the cancer originated. It is\nsuggested that this general property of cancer cells plays a major role in\ndetermining the behavior of the cancers, including their metastatic potential.",
"arxiv_id": "q-bio/0511021",
"authors": [
"Joseph Lotem",
"Dvir Netanely",
"Eytan Domany",
"Leo Sachs"
],
"categories": [
"q-bio.TO",
"q-bio.QM"
],
"doi": "10.1073/pnas.0509360102",
"title": "Human cancers over express genes that are specific to a variety of normal human tissues",
"url": "https://arxiv.org/abs/q-bio/0511021"
},
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