dorsal/arxiv
View SchemaAnalysis of evolution through competitive selection
| Authors | Morten Kloster |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0408027 |
| URL | https://arxiv.org/abs/q-bio/0408027 |
| DOI | 10.1103/PhysRevLett.95.168701 |
Abstract
Recent studies of in vitro evolution of DNA via protein binding indicate that the evolution behavior is qualitatively different in different parameter regimes. I here present a general theory that is valid for a wide range of parameters, and which reproduces and extends previous results. Specifically, the mean-field theory of a general translation-invariant model can be reduced to the basic diffusion equation with a dynamic boundary condition. The simple analytical form yields both quantitatively accurate predictions and valuable insight into the principles involved. In particular, I introduce a cutoff criterion for finite populations that illustrates both of these qualities.
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"abstract": "Recent studies of in vitro evolution of DNA via protein binding indicate that\nthe evolution behavior is qualitatively different in different parameter\nregimes. I here present a general theory that is valid for a wide range of\nparameters, and which reproduces and extends previous results. Specifically,\nthe mean-field theory of a general translation-invariant model can be reduced\nto the basic diffusion equation with a dynamic boundary condition. The simple\nanalytical form yields both quantitatively accurate predictions and valuable\ninsight into the principles involved. In particular, I introduce a cutoff\ncriterion for finite populations that illustrates both of these qualities.",
"arxiv_id": "q-bio/0408027",
"authors": [
"Morten Kloster"
],
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"physics.bio-ph"
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"doi": "10.1103/PhysRevLett.95.168701",
"title": "Analysis of evolution through competitive selection",
"url": "https://arxiv.org/abs/q-bio/0408027"
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