{
  "annotation_id": "33c3145b-99b3-4690-9b1d-ba2d40f597e7",
  "date_created": "2026-03-02T18:01:31.022000Z",
  "date_modified": "2026-03-02T18:01:31.022000Z",
  "file_hash": "c232b5b4ae304648403d7135762095e29908081ce6c59de1c4cc064a80cf5e41",
  "private": false,
  "record": {
    "abstract": "We consider a simple model for the unfolding of RNA tertiary structure under\ndynamic loading. The opening of such a structure is regarded as a two step\nprocess, each corresponding to the overcoming of a single energy barrier. The\nresulting two-barrier energy landscape accounts for the dependence of the\nunfolding kinetics on the pulling rate. Furthermore at intermediate force, the\ntwo barriers cannot be distinguished by the analysis of the opening kinetic,\nwhich turns out to be dominated by a single macro-barrier, whose properties\ndepend non-trivially on the two single barriers. Our results suggest that in\npulling experiments on RNA molecule containing tertiary structures, the details\nof the single kinetic barriers can only be obtained using a low pulling rate\nvalue, or in the high force regime.",
    "arxiv_id": "q-bio/0405017",
    "authors": [
      "Alberto Imparato",
      "Luca Peliti"
    ],
    "categories": [
      "q-bio.BM",
      "cond-mat.soft",
      "physics.bio-ph"
    ],
    "doi": "10.1140/epjb/e2004-00201-3",
    "journal_ref": "Eur. Phys. J. B 39: 357 (2004).",
    "title": "Kinetic barriers in RNA unzipping",
    "url": "https://arxiv.org/abs/q-bio/0405017"
  },
  "schema_id": "dorsal/arxiv",
  "source": {
    "execution_id": "4f279f94-14b7-45e5-8759-db6b8466c0d5",
    "id": "arXiv Dataset IDs",
    "type": "Model",
    "variant": "snapshot-2026-03-01",
    "version": "0.1.0"
  },
  "user_id": 1000002
}