dorsal/arxiv
View SchemaModel for Folding and Aggregation in RNA Secondary Structures
| Authors | Vishwesha Guttal, Ralf Bundschuh |
|---|---|
| Categories | |
| ArXiv ID | physics/0504140 |
| URL | https://arxiv.org/abs/physics/0504140 |
| DOI | 10.1103/PhysRevLett.96.018105 |
| Journal | Phys. Rev. Lett. 96, 018105 (2006) |
Abstract
We study the statistical mechanics of RNA secondary structures designed to have an attraction between two different types of structures as a model system for heteropolymer aggregation. The competition between the branching entropy of the secondary structure and the energy gained by pairing drives the RNA to undergo a `temperature independent' second order phase transition from a molten to an aggregated phase'. The aggregated phase thus obtained has a macroscopically large number of contacts between different RNAs. The partition function scaling exponent for this phase is \theta ~ 1/2 and the crossover exponent of the phase transition is \nu ~ 5/3. The relevance of these calculations to the aggregation of biological molecules is discussed.
{
"annotation_id": "338b3c0f-2e59-41e8-b846-9371d4a16692",
"date_created": "2026-03-02T18:00:57.173000Z",
"date_modified": "2026-03-02T18:00:57.173000Z",
"file_hash": "9bb2eefe834787c99712413e3b3e0c1a6feb4a140133c00ec8e6f55578836698",
"private": false,
"record": {
"abstract": "We study the statistical mechanics of RNA secondary structures designed to\nhave an attraction between two different types of structures as a model system\nfor heteropolymer aggregation. The competition between the branching entropy of\nthe secondary structure and the energy gained by pairing drives the RNA to\nundergo a `temperature independent\u0027 second order phase transition from a molten\nto an aggregated phase\u0027. The aggregated phase thus obtained has a\nmacroscopically large number of contacts between different RNAs. The partition\nfunction scaling exponent for this phase is \\theta ~ 1/2 and the crossover\nexponent of the phase transition is \\nu ~ 5/3. The relevance of these\ncalculations to the aggregation of biological molecules is discussed.",
"arxiv_id": "physics/0504140",
"authors": [
"Vishwesha Guttal",
"Ralf Bundschuh"
],
"categories": [
"physics.bio-ph",
"cond-mat.stat-mech",
"q-bio.BM"
],
"doi": "10.1103/PhysRevLett.96.018105",
"journal_ref": "Phys. Rev. Lett. 96, 018105 (2006)",
"title": "Model for Folding and Aggregation in RNA Secondary Structures",
"url": "https://arxiv.org/abs/physics/0504140"
},
"schema_id": "dorsal/arxiv",
"source": {
"execution_id": "6eae1e6c-1004-46b1-90f4-1c5b414b4d00",
"id": "arXiv Dataset IDs",
"type": "Model",
"variant": "snapshot-2026-03-01",
"version": "0.1.0"
},
"user_id": 1000002
}