dorsal/arxiv
View SchemaActivation and Protonation of Dinitrogen at the FeMo-Cofactor of Nitrogenase
| Authors | Johannes Kaestner, Sascha Hemmen, Peter E. Bloechl |
|---|---|
| Categories | |
| ArXiv ID | q-bio/0507012 |
| URL | https://arxiv.org/abs/q-bio/0507012 |
| DOI | 10.1063/1.2008227 |
| Journal | J. Chem. Phys. 123, 074306 (2005) |
Abstract
The protonation of N2 bound to the active center of nitrogenase has been investigated using state-of-the-art DFT calculations. Dinitrogen in the bridging mode is activated by forming two bonds to Fe sites, which results in a reduction of the energy for the first hydrogen transfer by 123 kJ/mol. The axial binding mode with open sulfur bridge is less reactive by 30 kJ/mol and the energetic ordering of the axial and bridged binding mode is reversed in favor of the bridging dinitrogen during the first protonation. Protonation of the central ligand is thermodynamically favorable but kinetically hindered. If the central ligand is protonated, the proton is transferred to dinitrogen following the second protonation. Protonation of dinitrogen at the Mo site does not lead to low-energy intermediates.
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"abstract": "The protonation of N2 bound to the active center of nitrogenase has been\ninvestigated using state-of-the-art DFT calculations. Dinitrogen in the\nbridging mode is activated by forming two bonds to Fe sites, which results in a\nreduction of the energy for the first hydrogen transfer by 123 kJ/mol. The\naxial binding mode with open sulfur bridge is less reactive by 30 kJ/mol and\nthe energetic ordering of the axial and bridged binding mode is reversed in\nfavor of the bridging dinitrogen during the first protonation. Protonation of\nthe central ligand is thermodynamically favorable but kinetically hindered. If\nthe central ligand is protonated, the proton is transferred to dinitrogen\nfollowing the second protonation. Protonation of dinitrogen at the Mo site does\nnot lead to low-energy intermediates.",
"arxiv_id": "q-bio/0507012",
"authors": [
"Johannes Kaestner",
"Sascha Hemmen",
"Peter E. Bloechl"
],
"categories": [
"q-bio.BM"
],
"doi": "10.1063/1.2008227",
"journal_ref": "J. Chem. Phys. 123, 074306 (2005)",
"title": "Activation and Protonation of Dinitrogen at the FeMo-Cofactor of Nitrogenase",
"url": "https://arxiv.org/abs/q-bio/0507012"
},
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